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Multicenter Study
. 2019 Feb 26;20(1):67.
doi: 10.1186/s12882-019-1255-8.

Epidemiology of acute kidney injury in hospitalized pregnant women in China

Diankun Liu  1 , Wenjuan He  1 , Yanqin Li  1 , Mengqi Xiong  1 , Long Wang  1 , Jingxin Huang  1 , Ling Jia  1 , Shuling Yuan  1 , Sheng Nie  2
Affiliations
Multicenter Study

Epidemiology of acute kidney injury in hospitalized pregnant women in China

Diankun Liu et al. BMC Nephrol. .

Abstract

Background: Epidemiologic data of acute kidney injury (AKI) during pregnancy is lacking in China. This study aims to determine the effect of pregnancy on the risk of AKI among hospitalized women of childbearing age, and to describe the incidence, risk factors and outcomes of AKI in hospitalized pregnant women in China.

Methods: We previously conducted a nationwide, multi-centered cohort of hospitalized patients from 25 hospitals in China during 1/1/2013 to 31/12/2015. Women of childbearing age (14-50 year) who had at least two serum creatinine tests within any 7-day window were selected as analysis set. Patient-level data were obtained from the electronic hospitalization information system and laboratory databases. AKI events were identified according to the creatinine criteria of Kidney Disease Improving Global Outcomes.

Results: Among 110,873 women of childbearing age, pregnant women (n = 10,920) had a 51% higher risk of AKI than non-pregnant women (n = 99,953). Community acquired and hospital acquired AKI occurred in 3.6% (n = 393) and 3.7% (n = 402) of the pregnant women, respectively, giving rise to an overall AKI incidence of 7.3%. While, hospital coding would have identified less than 5% of AKI episodes. The top three risk factors of AKI during pregnancy, ranked in order of decreasing population attributable fractions were pregnancy-induced hypertension syndrome (21.1%), acute fatty liver (13.5%), and chronic kidney disease (6.2%).

Conclusion: AKI in pregnancy is associated with increased maternal mortality rate, longer length of stay and higher daily cost. AKI is a common and severe complication during pregnancy in China.

Keywords: Acute kidney injury; Epidemiology; Pregnancy.

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Conflict of interest statement

Ethics approval and consent to participate

All patients provided written informed consent and parental consent has also been obtained for patients below 18 years old. The design of this cohort was approved by the Medical Ethics Committee of Nanfang Hospital (The approval number is NFEC-2014-098).

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Flowchart of study population selection
Fig. 2
Fig. 2
Incidence of AKI in various clinical settings. The number of patients with a clinical setting is indicated by n. HA-AKI, hospital-acquired AKI; CA-AKI, community-acquired AKI
See this image and copyright information in PMC

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