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Meta-Analysis
. 2019 Feb 26;19(1):53.
doi: 10.1186/s12890-019-0810-1.

The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis

Yue-Nan Ni  1 , Yan-Mei Wang  2 , Bin-Miao Liang  3 , Zong-An Liang  1
Affiliations
Meta-Analysis

The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis

Yue-Nan Ni et al. BMC Pulm Med. .

Abstract

Background: Studies investigating the role of hyperoxia in critically ill patients have reported conflicting results. We did this analysis to reveal the effect of hyperoxia in the patients admitted to the intensive care unit (ICU).

Methods: Electronic databases were searched for all the studies exploring the role of hyperoxia in adult patients admitted to ICU. The primary outcome was mortality. Random-effect model was used for quantitative synthesis of the adjusted odds ratio (aOR).

Results: We identified 24 trials in our final analysis. Statistical heterogeneity was found between hyperoxia and normoxia groups in patients with mechanical ventilation (I2 = 92%, P < 0.01), cardiac arrest(I2 = 63%, P = 0.01), traumatic brain injury (I2 = 85%, P < 0.01) and post cardiac surgery (I2 = 80%, P = 0.03). Compared with normoxia, hyperoxia was associated with higher mortality in overall patients (OR 1.22, 95% CI 1.12~1.33), as well as in the subgroups of cardiac arrest (OR 1.30, 95% CI 1.08~1.57) and extracorporeal life support (ELS) (OR 1.44, 95% CI 1.03~2.02).

Conclusions: Hyperoxia would lead to higher mortality in critically ill patients especially in the patients with cardiac arrest and ELS.

Keywords: Hyperoxia; Meta-analysis; Mortality.

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Conflict of interest statement

Ethics approval and consent to participate

Our study was approved by the Institutional Ethical Committee for Clinical and Biomedical Research of West China Hospital (Sichuan, China).

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

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Study flow
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Risk of bias
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Publication bias
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Mortality. OR, odds ratio; CI, confidence interval
See this image and copyright information in PMC

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