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Review
. 2019 Feb 25;17(1):eRB4596.
doi: 10.31744/einstein_journal/2019RB4596.

Immunoinflammatory mediators in the pathogenesis of diabetes mellitus

[Article in English, Portuguese]
Bárbara Festa Gomes  1 , Camila de Melo Accardo  1
Affiliations
Review

Immunoinflammatory mediators in the pathogenesis of diabetes mellitus

[Article in English, Portuguese]
Bárbara Festa Gomes et al. Einstein (Sao Paulo). .

Abstract
in English, Portuguese

Characterized as a metabolic syndrome with multiple consequences for the lives of patients, diabetes mellitus is also classified as a chronic non-communicable disease of great scope in the world. It is a complex disease, with different points of view, including the relation between inflammatory process, obesity and insulin resistance due to the performance of the various immunoinflammatory mediators - called adipokines - on glycemic homeostasis. Recent studies have precisely addressed this aspect for the development of drugs that assist in the protection of pancreatic ß cells from the damages arising from oxidative stress and inflammatory process, in order to control the hyperglycemic picture, which is characteristic of diabetes mellitus.

Caracterizado como uma síndrome metabólica de múltiplas consequências para a vida de seus portadores, o diabetes mellitus é também classificado como uma doença crônica não transmissível de grande abrangência no mundo. Trata-se de uma doença complexa, com diversos pontos de vista, dentre eles a relação entre processo inflamatório, obesidade e resistência à ação da insulina, devido à atuação dos diversos mediadores imunoinflamatórios, chamados de adipocinas, sobre a homeostase glicêmica. Recentes estudos têm abordado justamente este aspecto para o desenvolvimento de fármacos que auxiliem na proteção das células ß pancreáticas dos danos advindos do estresse oxidativo e processo inflamatório, de modo a controlar o quadro hiperglicêmico característico do diabetes mellitus.

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Figures

Figure 1
Figure 1. Immune inflammation of the adipose tissue related with diabetes mellitus and insulin resistance
See this image and copyright information in PMC

References

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