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Comment
. 2019 Apr;9(4):456.
doi: 10.1158/2159-8290.CD-NB2019-027. Epub 2019 Feb 27.

Uncovering Plasticity in Tumor Lipid Metabolism

No authors listed
Comment

Uncovering Plasticity in Tumor Lipid Metabolism

No authors listed. Cancer Discov. 2019 Apr.

Abstract

New research reveals a previously unknown plasticity in the lipid metabolism of some tumor types. Instead of relying on the canonical SCD pathway for fatty-acid desaturation, the cells exploit a different enzyme, FADS2, and upregulate this alternative route when SCD is inhibited.

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  • Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.
    Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, Van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TGP, Fendt SM. Vriens K, et al. Nature. 2019 Feb;566(7744):403-406. doi: 10.1038/s41586-019-0904-1. Epub 2019 Feb 6. Nature. 2019. PMID: 30728499 Free PMC article.

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