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Case Reports
. 2019 Feb 26;12(2):e227187.
doi: 10.1136/bcr-2018-227187.

Case of autoimmune polyglandular syndrome type 2: how we uncovered the diagnosis

Akhila Arya P V  1 , Jayesh Kumar  1 , Dileep Unnikrishnan  2 , Rishi Raj  2
Affiliations
Case Reports

Case of autoimmune polyglandular syndrome type 2: how we uncovered the diagnosis

Akhila Arya P V et al. BMJ Case Rep. .

Abstract

A 24-year-old man with no significant medical history presented to the medical clinic with vomiting and giddiness for 2 days, loss of appetite for 1 month and progressive fatigability for the preceding 4 months. On examination, he was found to be hypotensive and was admitted to the hospital for work-up. Considering his abnormal labs and physical findings, he was worked up and was diagnosed with primary adrenal insufficiency. On further work-up for the aetiology of his Addison's disease, he was found to have concurrent autoimmune thyroiditis and vitiligo. A final diagnosis of autoimmune polyglandular syndrome type 2 was made. The patient was started on hormone replacement therapy and reported improvement of symptoms on 3-month follow-up visit.

Keywords: adrenal disorders; endocrinology; immunology; thyroid disease.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Diffuse hyperpigmentation of the patient’s hands and nails.
Figure 2
Figure 2
White circle shows patches of vitiligo seen on the patient’s chest.
See this image and copyright information in PMC

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