Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Mar;12(1):8-13.
doi: 10.1055/s-0038-1668583. Epub 2018 Aug 27.

Behavior of Buccal Mucosal Squamous Cell Carcinoma: A Retrospective Study of 53 Carcinomas of This Anatomical Region

Paolo Cariati  1 , Almudena Cabello Serrano  1 , Ana Marin Fernandez  1 , Miguel Angel Julia Martinez  1 , Jose Fernandez Solis  1 , Ildefonso Martinez Lara  1
Affiliations
Review

Behavior of Buccal Mucosal Squamous Cell Carcinoma: A Retrospective Study of 53 Carcinomas of This Anatomical Region

Paolo Cariati et al. Craniomaxillofac Trauma Reconstr. 2019 Mar.

Abstract

The main aim of the present report is to study the pattern of distribution of cervical metastasis in buccal mucosa cancer and to discuss the various therapeutic options available. Fifty-three patients with squamous cell carcinoma of the buccal mucosa treated with tumorectomy and selective neck dissection were included in the study. We also studied the relationship between specific pathological features and overall survival. Level Ib was the most affected level, followed by level IIa. T stage, N stage, N involvement tumor thickness, extracapsular spread (ECS), and vascular invasion were associated with poorer outcomes regarding overall survival ( p < 0.001). Carcinoma of the buccal mucosa should be treated aggressively from the early stages. A large tumorectomy of the primary tumor is required to reduce the number of local recurrences. Moreover, we recommend performing a supraomohyoid neck dissection even in cT1N0 if there is a suspicion that the tumor thickness may be greater than 0.4 cm. The high risk of local recurrence obliges protection of the neck from a future cervical recurrence even in T1 small tumors. This could reduce the risk of cervical involvement during the follow-up and improve overall survival rates.

Keywords: buccal mucosa; early stages; locoregional failure; overall survival; squamous cell carcinoma; supraomohyoid neck dissection.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest None.

Figures

Fig. 1
Fig. 1
Relationship between T stage and overall survival. A major T stage is associated with worse survival rates.
Fig. 2
Fig. 2
Outcomes in relation to node involvement.
Fig. 3
Fig. 3
Outcomes in relation to ECS.
Fig. 4
Fig. 4
Outcomes in relation to N stage.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Ergun S, Warnakulasuriya S, Duman N et al.Micronuclear and sister chromatid exchange analyses in peripheral lymphocytes of patients with oral lichen planus--a pilot study. Oral Dis. 2009;15(07):499–504. - PubMed
    1. Siegel R L, Miller K D, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(01):5–29. - PubMed
    1. Capote A, Escorial V, Muñoz-Guerra M F, Rodríguez-Campo F J, Gamallo C, Naval L. Elective neck dissection in early-stage oral squamous cell carcinoma--does it influence recurrence and survival? Head Neck. 2007;29(01):3–11. - PubMed
    1. Monroe M M, Gross N D. Evidence-based practice: management of the clinical node-negative neck in early-stage oral cavity squamous cell carcinoma. Otolaryngol Clin North Am. 2012;45(05):1181–1193. - PubMed
    1. Sparano A, Weinstein G, Chalian A, Yodul M, Weber R. Multivariate predictors of occult neck metastasis in early oral tongue cancer. Otolaryngol Head Neck Surg. 2004;131(04):472–476. - PubMed

LinkOut - more resources