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Review
. 2019 Mar;12(1):8-13.
doi: 10.1055/s-0038-1668583. Epub 2018 Aug 27.

Behavior of Buccal Mucosal Squamous Cell Carcinoma: A Retrospective Study of 53 Carcinomas of This Anatomical Region

Paolo Cariati  1 , Almudena Cabello Serrano  1 , Ana Marin Fernandez  1 , Miguel Angel Julia Martinez  1 , Jose Fernandez Solis  1 , Ildefonso Martinez Lara  1
Affiliations
Review

Behavior of Buccal Mucosal Squamous Cell Carcinoma: A Retrospective Study of 53 Carcinomas of This Anatomical Region

Paolo Cariati et al. Craniomaxillofac Trauma Reconstr. 2019 Mar.

Abstract

The main aim of the present report is to study the pattern of distribution of cervical metastasis in buccal mucosa cancer and to discuss the various therapeutic options available. Fifty-three patients with squamous cell carcinoma of the buccal mucosa treated with tumorectomy and selective neck dissection were included in the study. We also studied the relationship between specific pathological features and overall survival. Level Ib was the most affected level, followed by level IIa. T stage, N stage, N involvement tumor thickness, extracapsular spread (ECS), and vascular invasion were associated with poorer outcomes regarding overall survival ( p < 0.001). Carcinoma of the buccal mucosa should be treated aggressively from the early stages. A large tumorectomy of the primary tumor is required to reduce the number of local recurrences. Moreover, we recommend performing a supraomohyoid neck dissection even in cT1N0 if there is a suspicion that the tumor thickness may be greater than 0.4 cm. The high risk of local recurrence obliges protection of the neck from a future cervical recurrence even in T1 small tumors. This could reduce the risk of cervical involvement during the follow-up and improve overall survival rates.

Keywords: buccal mucosa; early stages; locoregional failure; overall survival; squamous cell carcinoma; supraomohyoid neck dissection.

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Conflict of interest statement

Conflict of Interest None.

Figures

Fig. 1
Fig. 1
Relationship between T stage and overall survival. A major T stage is associated with worse survival rates.
Fig. 2
Fig. 2
Outcomes in relation to node involvement.
Fig. 3
Fig. 3
Outcomes in relation to ECS.
Fig. 4
Fig. 4
Outcomes in relation to N stage.
See this image and copyright information in PMC

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