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. 2018 Aug 3;28(1):209-214.
doi: 10.1007/s10068-018-0436-8. eCollection 2019 Feb.

Antidiabetic effect of an extract of nutricultured Brassica napus containing vanadium from a Jeju water concentrate

Ji-Hyun Yun  1 , Sung-Hwan Park  1 , Goo-Hee Choi  1 , In-Jae Park  1 , Jin-Ha Lee  2 , Ok-Hwan Lee  2 , Jung-Hyon Kim  3 , Yun-Hee Seo  4 , Ju-Hyun Cho  1
Affiliations

Antidiabetic effect of an extract of nutricultured Brassica napus containing vanadium from a Jeju water concentrate

Ji-Hyun Yun et al. Food Sci Biotechnol. .

Abstract

The purpose of this study was to determine the antidiabetic effect of an extract of nutricultured Brassica napus containing vanadium (BECV). The BECV was prepared following nutriculture of B. napus with a Jeju water vanadium concentrate for 7 day. The BECV was administered to db/db mice for 8 weeks at different dosages (0.028, 0.14, and 0.7 μg/kg; as vanadium concentration in BECV). After 8 weeks, the BECV results showed mouse blood glucose concentrations to significantly decrease, in a dose-dependent manner, compared with the results for control mice. In addition, the concentrations of triglyceride, total cholesterol, and glycated hemoglobin were significantly lower after 8 weeks of administration of 0.7 μg/kg BECV. Therefore, the BECV may have protective effects against type 2 diabetes.

Keywords: Antidiabetic effect; Brassica napus extract; Vanadium; db/db mouse.

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Figures

Fig. 1
Fig. 1
Weekly changes in body weight of db/db mice administered BECV, metformin, or water (control) orally. Data points indicate mean ± SD (n = 6 in each group)
Fig. 2
Fig. 2
Glycated hemoglobin (HbA1c) levels in db/db mice administered with BECV, metformin, or water (control) at the end of the 8-week treatment period. Data points indicate mean ± SD (n = 6 in each group). **p < 0.01
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