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Editorial
. 2019 Mar;16(2):145-156.
doi: 10.2217/pme-2018-0102. Epub 2019 Feb 28.

Clinical and research applications of a brain tumor tissue bank in the age of precision medicine

James Snyder  1   2 , Laila M Poisson  2 , Houtan Noushmehr  2 , Ana V Castro  2 , Ana C deCarvalho  2 , Adam Robin  2 , Abir Mukherjee  3 , Ian Lee  2 , Tobias Walbert  1   2
Affiliations
Editorial

Clinical and research applications of a brain tumor tissue bank in the age of precision medicine

James Snyder et al. Per Med. 2019 Mar.

Abstract

Marked progress has been made recently in the treatment of patients with central nervous system (CNS) tumors, especially gliomas. However, because of the relative rarity of these tumors compared with other malignancies, advances in the molecular/genetic analysis leading to future targeted treatments rely on systematic, organized tissue banking. Several large multi-institutional efforts have utilized major tissue banks that have yielded valuable information that may lead to a better understanding of the pathogenesis of CNS tumors. This manuscript portrays best practices for the establishment and maintenance of a well-organized CNS tumor bank. In addition, annotation for clinical and research needs is explained. The potential benefits to clinical care, as well as basic science and translational research are also described.

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Conflict of interest statement

Financial & competing interests disclosure

This work was supported by the Henry Ford Health System Department of Neurosurgery and the Hermelin Brain Tumor Center. Additionally, LMP, HN, ACD, and AM are supported by NCI R01CA222146 and HN, LMP, ACD, and AVC are supported by DOD CA170278. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Figures

<b>Figure 1.</b>
Figure 1.. Contributions of the team.
A multidisciplinary team is required for successful biobanking (blue arrows) and the sharing of knowledge across this team promotes successful research (blue circle).
<b>Figure 2.</b>
Figure 2.. A volcano plot created in TCGA Biolinks GUI.
The menu bar on the left shows different analyses available with the volcano plot item highlighted. The panel on the right shows the controls available for the current analysis; all aspects of the plot are configurable here.
See this image and copyright information in PMC

References

    1. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. WHO Classification of Tumours of the Central Nervous System (4th Edition) IARC Press; Lyon, France: 2016.
    1. Campbell LD, Astrin JJ, DeSouza Y, et al. The 2018 revision of the ISBER Best Practices: summary of changes and the editorial team's development process. Biopreserv Biobank. 2018;16(1):3–6. - PMC - PubMed

    2. • Highlights the latest update of the comprehensive International Society for Biological and Environmental Repositories best practices in biobanking.

    1. Rosenblum ML, Mikkelsen T. Developing a brain tumor center. J. Neurooncol. 2004;69(1-3):169–180. - PubMed

    2. • Discusses the early Hermelin Brain Tumor Center Tissue Bank development and funding mechanism.

    1. Ostrom QT, Devine K, Fulop J, et al. Brain tumor biobanking in the precision medicine era: building a high-quality resource for translational research in neuro-oncology. Neurooncol. Pract. 2017;4(4):220–228. - PMC - PubMed

    2. • Focusing also on central nervous system (CNS) banking, this paper provides a complementary discussion of governance and funding.

    1. Schmitt S, Kynast K, Schirmacher P, Herpel E. Challenges for quality management in implementation, maintenance, and sustainability of research tissue biobanks. Virchows Archiv. 2016;468(1):93–99. - PubMed

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