. 2019 May;33(5):1296-1301.

doi: 10.1038/s41375-019-0428-6. Epub 2019 Feb 28.

PIM1 inhibition effectively enhances plerixafor-induced HSC mobilization by counteracting CXCR4 upregulation and blocking CXCL12 secretion

Tony Andreas Müller¹, Sandra Pennisi¹, Anabel Zwick^{1

2

3}, Sarah Decker¹, Claudius Klein¹, Benjamin Rister¹, Alina Rudorf^{1

3}, Sandra Kissel¹, Marie Follo¹, Ralph Wäsch¹, Anna Lena Illert^{1

3}, Dietmar Pfeifer¹, Robert Oostendorp², Claudia Waskow⁴, Christine Dierks^#^{5

6}, Justus Duyster^#^{1

3}

Affiliations

¹ Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
² Department of Internal Medicine III, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675, Munich, Germany.
³ German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁴ Regeneration in Hematopoiesis and Animal Models in Hematopoiesis, Institute for Immunology, Medical Faculty Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
⁵ Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany. christine.dierks@uniklinik-freiburg.de.
⁶ Center for Biological Signaling Studies, EXC294, BIOSS, Freiburg, Germany. christine.dierks@uniklinik-freiburg.de.

^# Contributed equally.

PMID: 30816332
DOI: 10.1038/s41375-019-0428-6

PIM1 inhibition effectively enhances plerixafor-induced HSC mobilization by counteracting CXCR4 upregulation and blocking CXCL12 secretion

Tony Andreas Müller et al. Leukemia. 2019 May.

. 2019 May;33(5):1296-1301.

doi: 10.1038/s41375-019-0428-6. Epub 2019 Feb 28.

Authors

Affiliations

¹ Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
² Department of Internal Medicine III, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675, Munich, Germany.
³ German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁴ Regeneration in Hematopoiesis and Animal Models in Hematopoiesis, Institute for Immunology, Medical Faculty Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
⁵ Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany. christine.dierks@uniklinik-freiburg.de.
⁶ Center for Biological Signaling Studies, EXC294, BIOSS, Freiburg, Germany. christine.dierks@uniklinik-freiburg.de.

^# Contributed equally.

PMID: 30816332
DOI: 10.1038/s41375-019-0428-6

No abstract available

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References

1. Aiuti A, Webb IJ, Bleul C, Springer T, Gutierrez-Ramos JC. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med. 1997;185:111–20. - DOI
1. Möhle R, Bautz F, Rafii S, Moore MA, Brugger W, Kanz L. The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. Blood. 1998;91:4523–30. - PubMed
1. Petit I, Szyper-Kravitz M, Nagler A, Lahav M, Peled A, Habler L, et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol. 2002;3:687–94. - DOI
1. Peled A, Petit I, Kollet O, Magid M, Ponomaryov T, Byk T, et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science. 1999;283:845–8. - DOI
1. Sugiyama T, Kohara H, Noda M, Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity. 2006;25:977–88. - DOI

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PIM1 inhibition effectively enhances plerixafor-induced HSC mobilization by counteracting CXCR4 upregulation and blocking CXCL12 secretion

Affiliations

PIM1 inhibition effectively enhances plerixafor-induced HSC mobilization by counteracting CXCR4 upregulation and blocking CXCL12 secretion

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