PIM1 inhibition effectively enhances plerixafor-induced HSC mobilization by counteracting CXCR4 upregulation and blocking CXCL12 secretion

Tony Andreas Müller¹, Sandra Pennisi¹, Anabel Zwick^{1

2

3}, Sarah Decker¹, Claudius Klein¹, Benjamin Rister¹, Alina Rudorf^{1

3}, Sandra Kissel¹, Marie Follo¹, Ralph Wäsch¹, Anna Lena Illert^{1

3}, Dietmar Pfeifer¹, Robert Oostendorp², Claudia Waskow⁴, Christine Dierks^#^{5

6}, Justus Duyster^#^{1

3}

Affiliations

¹ Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
² Department of Internal Medicine III, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675, Munich, Germany.
³ German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁴ Regeneration in Hematopoiesis and Animal Models in Hematopoiesis, Institute for Immunology, Medical Faculty Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
⁵ Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany. christine.dierks@uniklinik-freiburg.de.
⁶ Center for Biological Signaling Studies, EXC294, BIOSS, Freiburg, Germany. christine.dierks@uniklinik-freiburg.de.

^# Contributed equally.

Tony Andreas Müller et al. Leukemia. 2019 May.

. 2019 May;33(5):1296-1301.

doi: 10.1038/s41375-019-0428-6. Epub 2019 Feb 28.

¹ Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
² Department of Internal Medicine III, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675, Munich, Germany.
³ German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁴ Regeneration in Hematopoiesis and Animal Models in Hematopoiesis, Institute for Immunology, Medical Faculty Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
⁵ Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany. christine.dierks@uniklinik-freiburg.de.
⁶ Center for Biological Signaling Studies, EXC294, BIOSS, Freiburg, Germany. christine.dierks@uniklinik-freiburg.de.

^# Contributed equally.

No abstract available

References

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