Acute dual antiplatelet therapy for minor ischaemic stroke or transient ischaemic attack

Yongjun Wang^{1

2

3

4}, S Claiborne Johnston⁵, Philip M Bath⁶, James C Grotta⁷, Yuesong Pan^{8

2

3

4}, Pierre Amarenco⁹, Yilong Wang^{8

2

3

4}, Tabassome Simon^{10

11

12}, Jong Sung Kim¹³, Jiann-Shing Jeng¹⁴, Liping Liu^{8

2

3

4}, Yi Lin¹⁵, Ka Sing Lawrence Wong¹⁶, David Wang^{17

18}, Hao Li^{8

2

3

4}

Affiliations

¹ Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China yongjunwang@ncrcnd.org.cn.
² China National Clinical Research Center for Neurological Diseases, Beijing, China.
³ Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
⁴ Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
⁵ Dean's Office, Dell Medical School, University of Texas at Austin, Austin, TX, USA.
⁶ Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.
⁷ Clinical Innovation and Research Institute, Memorial Hermann Hospital, Houston, TX, USA.
⁸ Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
⁹ Department of Neurology and Stroke Center, Bichat University Hospital and Paris-Diderot, Sorbonne University, Paris, France.
¹⁰ Department of Clinical Pharmacology and Clinical Research Platform of East of Paris, Assistance Publique-Hôpitaux de Paris, Paris, France.
¹¹ Department of Clinical Pharmacology, Sorbonne Université, Paris, France.
¹² French Alliance for Cardiovascular Clinical Trials, Paris, France.
¹³ Department of Neurology, University of Ulsan, Asan Medical Center, Seoul, South Korea.
¹⁴ Department of Neurology and Stroke Center, National Taiwan University Hospital, Taipei, Taiwan.
¹⁵ Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
¹⁶ Division of Neurology, Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
¹⁷ Illinois Neurological Institute Stroke Network, OSF Healthcare System, Peoria, IL, USA.
¹⁸ Department of Neurology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.

PMID: 30819687
PMCID: PMC6394376
DOI: 10.1136/bmj.l895

Acute dual antiplatelet therapy for minor ischaemic stroke or transient ischaemic attack

Yongjun Wang et al. BMJ. 2019.

. 2019 Feb 28:364:l895.

doi: 10.1136/bmj.l895.

Authors

Affiliations

¹ Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China yongjunwang@ncrcnd.org.cn.
² China National Clinical Research Center for Neurological Diseases, Beijing, China.
³ Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
⁴ Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
⁵ Dean's Office, Dell Medical School, University of Texas at Austin, Austin, TX, USA.
⁶ Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.
⁷ Clinical Innovation and Research Institute, Memorial Hermann Hospital, Houston, TX, USA.
⁸ Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
⁹ Department of Neurology and Stroke Center, Bichat University Hospital and Paris-Diderot, Sorbonne University, Paris, France.
¹⁰ Department of Clinical Pharmacology and Clinical Research Platform of East of Paris, Assistance Publique-Hôpitaux de Paris, Paris, France.
¹¹ Department of Clinical Pharmacology, Sorbonne Université, Paris, France.
¹² French Alliance for Cardiovascular Clinical Trials, Paris, France.
¹³ Department of Neurology, University of Ulsan, Asan Medical Center, Seoul, South Korea.
¹⁴ Department of Neurology and Stroke Center, National Taiwan University Hospital, Taipei, Taiwan.
¹⁵ Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
¹⁶ Division of Neurology, Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
¹⁷ Illinois Neurological Institute Stroke Network, OSF Healthcare System, Peoria, IL, USA.
¹⁸ Department of Neurology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.

PMID: 30819687
PMCID: PMC6394376
DOI: 10.1136/bmj.l895

Abstract

Yongjun Wang and colleagues discuss recent evidence for using dual antiplatelet therapy to reduce recurrence of stroke or transient ischaemic attack

PubMed Disclaimer

Conflict of interest statement

Competing interests: We have read and understood BMJ policy on declaration of interests and declare that the study was supported by grants from the Ministry of Science and Technology of the People’s Republic of China (2016YFC0901001, 2016YFC0901002, 2017YFC1310901, 2018YFC1311700 and 2018YFC1311706), and grants from Beijing Municipal Commission of Health and Family Planning (No 2016-1-2041, SML20150502).

References

1. Wang Y, Wang Y, Zhao X, et al. CHANCE Investigators Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med 2013;369:11-9. 10.1056/NEJMoa1215340 - DOI - PubMed
1. Johnston SC, Easton JD, Farrant M, et al. Clinical Research Collaboration, Neurological Emergencies Treatment Trials Network, and the POINT Investigators Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA. N Engl J Med 2018;379:215-25. 10.1056/NEJMoa1800410 - DOI - PMC - PubMed
1. Prasad K, Siemieniuk R, Hao Q, et al. Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke: a clinical practice guideline. BMJ 2018;363:k5130. 10.1136/bmj.k5130 - DOI - PubMed
1. Hao Q, Tampi M, O’Donnell M, Foroutan F, Siemieniuk RA, Guyatt G. Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke or high risk transient ischaemic attack: systematic review and meta-analysis. BMJ 2018;363:k5108. 10.1136/bmj.k5108 - DOI - PMC - PubMed
1. Powers WJ, Rabinstein AA, Ackerson T, et al. American Heart Association Stroke Council 2018 Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2018;49:e46-110. 10.1161/STR.0000000000000158 - DOI - PubMed

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Acute dual antiplatelet therapy for minor ischaemic stroke or transient ischaemic attack

Affiliations

Acute dual antiplatelet therapy for minor ischaemic stroke or transient ischaemic attack

Authors

Affiliations

Abstract

Conflict of interest statement

References

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical