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. 2019 Feb 12:10:17.
doi: 10.4103/ijpvm.IJPVM_174_18. eCollection 2019.

Effect of Vitamin D Supplement on Mood Status and Inflammation in Vitamin D Deficient Type 2 Diabetic Women with Anxiety: A Randomized Clinical Trial

Siavash Fazelian  1 , Reza Amani  2 , Zamzam Paknahad  1 , Soleiman Kheiri  3 , Leila Khajehali  4
Affiliations

Effect of Vitamin D Supplement on Mood Status and Inflammation in Vitamin D Deficient Type 2 Diabetic Women with Anxiety: A Randomized Clinical Trial

Siavash Fazelian et al. Int J Prev Med. .

Abstract

Background: Vitamin D plays an important role in nervous health and depression. Vitamin D deficiency and anxiety affect diabetic status. The purpose of this study was to determine the effect of vitamin D supplementation on anxiety, depression, and inflammation in diabetic women with anxiety.

Methods: In this randomized controlled trial, totally 51 women with type 2 diabetes (T2DM) and vitamin D deficiency were randomly allocated to receive one oral pearl of 50,000 IU vitamin D3 (26 women) or a placebo (25 women) fortnightly for 16 weeks. Anthropometric indices, sun exposure, dietary intake, depression, anxiety, and stress scores and biochemical biomarkers including high sensitivity C-reactive protein (hs-CRP) and interleukin-10 (IL-10) were measured at the baseline and after 16-week supplementation.

Results: Mean ± SD age of participant was 47.43 ± 9.57 years old. Baseline values were not different between the groups. Anxiety score changes were significantly lower in vitamin D group than the controls (P = 0.001). Within group comparison indicated that depression in supplement group with lower vitamin D levels was significantly reduced. Serum hs-CRP reduced (P = 0.01), while IL-10 concentrations increased (P = 0.04) in the intervention group.

Conclusions: Vitamin D supplementation can improve mood status and anti-inflammatory biomarkers in female diabetics with anxiety and vitamin D deficiency.

Keywords: Anxiety; Vitamin D; diabetes; inflammation; women.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Algorithm of study participants in the two groups
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References

    1. DeLuca GC, Kimball SM, Kolasinski J, Ramagopalan SV, Ebers GC. Review: The role of Vitamin D in nervous system health and disease. Neuropathol Appl Neurobiol. 2013;39:458–84. - PubMed
    1. Holick MF. The Vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017;18:153–65. - PubMed
    1. Kazemi A, Sharifi F, Jafari N, Mousavinasab N. High prevalence of Vitamin D deficiency among pregnant women and their newborns in an Iranian population. J Womens Health (Larchmt) 2009;18:835–9. - PubMed
    1. Gale C, Oakley-Browne M. Generalised anxiety disorder. Evidence Based Ment Health. 2004;7:32–3.
    1. Smith KJ, Béland M, Clyde M, Gariépy G, Pagé V, Badawi G, et al. Association of diabetes with anxiety: A systematic review and meta-analysis. J Psychosom Res. 2013;74:89–99. - PubMed