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. 2019;23(3):246-250.
doi: 10.1007/s12603-018-1149-7.

Serum SIRT1 Is Associated with Frailty and Adipokines in Older Adults

L Ma  1 , H Niu, G Sha, Y Zhang, P Liu, Y Li
Affiliations

Serum SIRT1 Is Associated with Frailty and Adipokines in Older Adults

L Ma et al. J Nutr Health Aging. 2019.

Abstract

Background: Because frailty is a major health concern among older patients, identifying frailty-related biomarkers will help in the early detection and prevention of frailty. Thus, we aimed to determine the association between circulating levels of silent mating-type information regulation 2 homolog 1 (SIRT1) and frailty.

Methods: We assessed circulating SIRT1 levels in 16 robust, 74 prefrail, and 40 frail older adults. Frailty was diagnosed based on the Fried phenotype. Circulating cytokine and adipokine (e.g., vaspin, adiponectin, and leptin) levels were assessed. Differences in SIRT1 levels among the three subject groups were compared; correlations of SIRT1 levels with physical function and adipokine and cytokine levels were analyzed.

Results: Serum SIRT1 levels were significantly higher among frail older adults than among robust ones. Older adults with slowness or weight loss had high SIRT1 levels. Serum SIRT1 levels negatively correlated with gait speed, even after adjustment for age and sex; age; and insulin, vaspin, and leptin levels; they correlated negatively with phospholipase A2 levels.

Conclusions: High SIRT1 levels were observed in frail elderly patients and were correlated with decreased physical function. Insulin and adipokine levels might be the link between SIRT1 and frailty, whereas inflammation may not be involved in this process.

Keywords: SIRT1; adipokine; frailty; insulin; older adult.

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
Comparison of SIRT1 levels in different groups
Figure 2
Figure 2
Correlation of SIRT1 levels with physical function, age, and BMI
Figure 3
Figure 3
Correlation of SIRT1 levels with inflammatory markers and levels of insulin and adipokines.
See this image and copyright information in PMC

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References

    1. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in Older Adults: Evidence for a Phenotype. Journals Gerontol Ser A Biol Sci Med Sci. 2001;56:M146–57. 10.1093/gerona/56.3.M146 - DOI - PubMed
    1. Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci. 2007;62:722–727. 10.1093/gerona/62.7.722 PubMed PMID: 17634318. - DOI - PubMed
    1. Ma L, Zhang L, Tang Z, Sun F, Diao L, Wang J, et al. Use of the frailty index in evaluating the prognosis of older people in Beijing: A cohort study with an 8-year follow-up. Arch Gerontol Geriatr. 2016;64:172–177. 10.1016/j.archger.2015.11.002 PubMed PMID: 26778493. - DOI - PubMed
    1. Ma L, Li Y. SIRT1: Role in cardiovascular biology. Clin Chim Acta. 2015;440:8–15. 10.1016/j.cca.2014.10.036 PubMed PMID: 25444742. - DOI - PubMed
    1. Baur JA, Ungvari Z, Minor R L, Couteur D d, Cabo R. Are sirtuins viable targets for improving healthspan and lifespan. Nat Rev Drug Discov. 2012;11:443–461. 10.1038/nrd3738 PubMed PMID: 22653216, PMCID 4684642. - DOI - PMC - PubMed

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