Functional Electrical Stimulation Changes Muscle Oxygenation in Patients with Chronic Obstructive Pulmonary Disease During Moderate-Intensity Exercise: A Secondary Analysis

Abstract

We previously showed that functional electrical stimulation during cycle ergometry (FES-cycling) increased oxygen consumption (VO₂), indicating that metabolism during exercise was increased. However, the effects on muscle oxygenation have never been studied. The aim of this secondary analysis was to analyse changes in muscle oxygenation during an FES-cycling session. Eight patients with chronic obstructive pulmonary disease who were participating in a pulmonary rehabilitation programme were enrolled. Each participant carried out 30 minutes of cycle ergometry with a constant load at 50% of peak oxygen uptake, either (i) with FES or (ii) without (Placebo-FES). Oxygenation of the vastus lateralis (VL) muscle over time was measured using near-infrared spectroscopy (NIRS) during both sessions. External power output on the cycle ergometer was the same in both conditions. There were no differences in dyspnoea between the groups, although the concentrations of deoxygenated haemoglobin and myoglobin (deoxy(Hb + Mb)) in the VL were significantly greater during Placebo-FES than FES-Cycling (respectively +212 ± 65% vs. +84 ± 29%; p < 0.001), as was the decrease in muscle oxygen saturation (StO₂) (p < 0.001). When adjusted for VO₂, there was a greater increase over time in the deoxy(Hb + Mb)/VO₂ ratio during Placebo-FES than FES-cycling (p < 0.0001). FES-cycling could be a useful strategy to decrease muscular deoxy(Hb + Mb) and limit decreases in muscle StO₂, however this should be confirmed in larger studies.

Keywords: COPD; functional electrical stimulation cycling; muscle oxygenation; pulmonary rehabilitation.