New Applications of Old Drugs as Novel Therapies in Idiopathic Pulmonary Fibrosis. Metformin, Hydroxychloroquine, and Thyroid Hormone
- PMID: 30822095
- PMCID: PMC7051474
- DOI: 10.1164/rccm.201809-1700RR
New Applications of Old Drugs as Novel Therapies in Idiopathic Pulmonary Fibrosis. Metformin, Hydroxychloroquine, and Thyroid Hormone
Comment on
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Cholesterol-modified Hydroxychloroquine-loaded Nanocarriers in Bleomycin-induced Pulmonary Fibrosis.Sci Rep. 2017 Sep 6;7(1):10737. doi: 10.1038/s41598-017-11450-3. Sci Rep. 2017. PMID: 28878315 Free PMC article.
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Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.Nat Med. 2018 Jan;24(1):39-49. doi: 10.1038/nm.4447. Epub 2017 Dec 4. Nat Med. 2018. PMID: 29200204 Free PMC article.
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Metformin reverses established lung fibrosis in a bleomycin model.Nat Med. 2018 Aug;24(8):1121-1127. doi: 10.1038/s41591-018-0087-6. Epub 2018 Jul 2. Nat Med. 2018. PMID: 29967351 Free PMC article.
References
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- American Thoracic Society European Respiratory Society American Thoracic Society/European Respiratory Society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias Am J Respir Crit Care Med 2002165277–304.[Published erratum appears in Am J Respir Crit Care Med 166:426.] - PubMed
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