doi: 10.1136/adc.61.2.182.
Interleukin-1 in malnutrition
- PMID: 3082298
- PMCID: PMC1777567
- DOI: 10.1136/adc.61.2.182
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Interleukin-1 in malnutrition
Arch Dis Child.
1986 Feb.
Abstract
The effect of malnutrition on the in vitro production of interleukin-1 by lipopolysaccharide stimulated circulating monocytes has been investigated in children suffering from kwashiorkor and marasmus. The interleukin-1 activity was significantly lower in children with severe malnutrition. Furthermore, macrophages from children with kwashiorkor produced factors that suppressed mouse thymocyte proliferation. These observations show a significant impairment of macrophage function and provide a mechanism for the suppression of cellular immunity in malnutrition.
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