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. 1986 Feb;61(2):182-5.
doi: 10.1136/adc.61.2.182.

Interleukin-1 in malnutrition

P Bhaskaram, B Sivakumar

Interleukin-1 in malnutrition

P Bhaskaram et al. Arch Dis Child. 1986 Feb.

Abstract

The effect of malnutrition on the in vitro production of interleukin-1 by lipopolysaccharide stimulated circulating monocytes has been investigated in children suffering from kwashiorkor and marasmus. The interleukin-1 activity was significantly lower in children with severe malnutrition. Furthermore, macrophages from children with kwashiorkor produced factors that suppressed mouse thymocyte proliferation. These observations show a significant impairment of macrophage function and provide a mechanism for the suppression of cellular immunity in malnutrition.

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