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. 1986 Mar 15;292(6522):721-3.
doi: 10.1136/bmj.292.6522.721.

Amodiaquine induced agranulocytosis and liver damage

K A Neftel, W Woodtly, M Schmid, P G Frick, J Fehr

Amodiaquine induced agranulocytosis and liver damage

K A Neftel et al. Br Med J (Clin Res Ed). .

Abstract

Seven cases of agranulocytosis and two of liver damage that were probably due to amodiaquine treatment were studied. In five cases agranulocytosis was combined with liver damage, and in one case of primary liver damage moderate neutropenia was present. Three patients died. High total doses or prolonged duration of treatment, or both, appear to favour the occurrence of these reactions. The clustering of five of the seven cases of agranulocytosis within six months in one medical centre indicates that the risk to benefit ratio of amodiaquine for malaria prophylaxis should be re-evaluated.

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References

    1. Br Med J. 1957 Apr 20;1(5024):932 - PubMed
    1. Arthritis Rheum. 1959 Oct;2:396-402 - PubMed
    1. Schweiz Med Wochenschr. 1983 Dec 17;113(50):1912-3 - PubMed
    1. JAMA. 1962 Feb 24;179:598-601 - PubMed
    1. Arthritis Rheum. 1959 Oct;2:403-13 - PubMed

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