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Case Reports
. 2019 Feb 28;12(2):e224619.
doi: 10.1136/bcr-2018-224619.

Hydroxychloroquine-induced inverse psoriasis

Asad Ullah  1 , Hassan Zeb  1 , Zeeshan Khakwani  1 , Frederick T Murphy  2
Affiliations
Case Reports

Hydroxychloroquine-induced inverse psoriasis

Asad Ullah et al. BMJ Case Rep. .

Abstract

A 65-year-old woman presented to our rheumatology clinic with pain and swelling of multiple joints of her hands. After a thorough evaluation, she was diagnosed with rheumatoid arthritis and was started on hydroxychloroquine therapy. A week later, she presented to our clinic with an acute condition and reported that after taking hydroxychloroquine for a few days she developed multiple rashes, most prominent at skin folds around her breasts, neck, axillae and buttocks. The rashes were characteristic of inverse psoriasis. Hydroxychloroquine was discontinued and the patient was started on methotrexate therapy that resulted in resolution of her rashes in a week.

Keywords: pharmacology and therapeutics; skin.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Erythematous macular rash involving the face and neck.
Figure 2
Figure 2
Erythematous macular rash involving the neck and chest.
Figure 3
Figure 3
Erythematous maculopapular rash with a silver hue involving the left breast and axilla.
See this image and copyright information in PMC

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