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Comment
. 2019 Mar;9(3):326-328.
doi: 10.1158/2159-8290.CD-19-0034.

Metabolism Drives Carcinogenesis and Maintenance of Pancreatic Tumors

Christopher J Halbrook  1 , Barbara S Nelson  1   2 , Costas A Lysstiotis  3   4   5
Affiliations
Comment

Metabolism Drives Carcinogenesis and Maintenance of Pancreatic Tumors

Christopher J Halbrook et al. Cancer Discov. 2019 Mar.

Abstract

In this issue of Cancer Discovery, Carrer and colleagues find that early events in pancreatic tumorigenesis are driven by altered acetyl-CoA metabolism, where targeting this axis in established cancer models impairs tumor growth. This work provides new insights into the roles of acetyl-CoA in pancreatic cancer and underscores the value of studying early events in carcinogenesis to yield new treatment strategies.See related article by Carrer et al., p. 416.

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Comment on

  • Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis.
    Carrer A, Trefely S, Zhao S, Campbell SL, Norgard RJ, Schultz KC, Sidoli S, Parris JLD, Affronti HC, Sivanand S, Egolf S, Sela Y, Trizzino M, Gardini A, Garcia BA, Snyder NW, Stanger BZ, Wellen KE. Carrer A, et al. Cancer Discov. 2019 Mar;9(3):416-435. doi: 10.1158/2159-8290.CD-18-0567. Epub 2019 Jan 9. Cancer Discov. 2019. PMID: 30626590 Free PMC article.

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