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. 2019 Mar 1;9(3):e024939.
doi: 10.1136/bmjopen-2018-024939.

Uppsala Longitudinal Adolescent Depression Study (ULADS)

Iman Alaie  1 , Anna Philipson  2 , Richard Ssegonja  3 , Lars Hagberg  2 , Inna Feldman  3 , Filipa Sampaio  3 , Margareta Möller  2 , Hans Arinell  1   4 , Mia Ramklint  1   4 , Aivar Päären  1 , Lars von Knorring  4 , Gunilla Olsson  1 , Anne-Liis von Knorring  1 , Hannes Bohman  1 , Ulf Jonsson  1   5   6
Affiliations

Uppsala Longitudinal Adolescent Depression Study (ULADS)

Iman Alaie et al. BMJ Open. .

Abstract

Purpose: To present the Uppsala Longitudinal Adolescent Depression Study, initiated in Uppsala, Sweden, in the early 1990s. The initial aim of this epidemiological investigation was to study the prevalence, characteristics and correlates of adolescent depression, and has subsequently expanded to include a broad range of social, economic and health-related long-term outcomes and cost-of-illness analyses.

Participants: The source population was first-year students (aged 16-17) in upper-secondary schools in Uppsala during 1991-1992, of which 2300 (93%) were screened for depression. Adolescents with positive screening and sex/age-matched peers were invited to a comprehensive assessment. A total of 631 adolescents (78% females) completed this assessment, and 409 subsequently completed a 15-year follow-up assessment. At both occasions, extensive information was collected on mental disorders, personality and psychosocial situation. Detailed social, economic and health-related data from 1993 onwards have recently been obtained from the Swedish national registries for 576 of the original participants and an age-matched reference population (N≥200 000).

Findings to date: The adolescent lifetime prevalence of a major depressive episode was estimated to be 11.4%. Recurrence in young adulthood was reported by the majority, with a particularly poor prognosis for those with a persistent depressive disorder or multiple somatic symptoms. Adolescent depression was also associated with an increased risk of other adversities in adulthood, including additional mental health conditions, low educational attainment and problems related to intimate relationships.

Future plans: Longitudinal studies of adolescent depression are rare and must be responsibly managed and utilised. We therefore intend to follow the cohort continuously by means of registries. Currently, the participants are approaching mid-adulthood. At this stage, we are focusing on the overall long-term burden of adolescent depression. For this purpose, the research group has incorporated expertise in health economics. We would also welcome extended collaboration with researchers managing similar datasets.

Keywords: epidemiology; health economics.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Phases of the study and data available from each phase. CRP, C-reactive protein.
Figure 2
Figure 2
Flow chart of the screening procedure and baseline diagnostic assessment.
See this image and copyright information in PMC

References

    1. Gore FM, Bloem PJN, Patton GC, et al. . Global burden of disease in young people aged 10–24 years: a systematic analysis. The Lancet 2011;377:2093–102. 10.1016/S0140-6736(11)60512-6 - DOI - PubMed
    1. Vos T, Barber RM, Bell B, et al. . Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet 2015;386:743–800. 10.1016/S0140-6736(15)60692-4 - DOI - PMC - PubMed
    1. Otte C, Gold SM, Penninx BW, et al. . Major depressive disorder. Nat Rev Dis Primers 2016;2:16065 10.1038/nrdp.2016.65 - DOI - PubMed
    1. Kessler RC, Bromet EJ. The epidemiology of depression across cultures. Annu Rev Public Health 2013;34:119–38. 10.1146/annurev-publhealth-031912-114409 - DOI - PMC - PubMed
    1. Chisholm D, Sweeny K, Sheehan P, et al. . Scaling-up treatment of depression and anxiety: a global return on investment analysis. Lancet Psychiatry 2016;3:415–24. 10.1016/S2215-0366(16)30024-4 - DOI - PubMed

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