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. 1986 Feb;39(2):259-65.
doi: 10.7164/antibiotics.39.259.

Biosynthesis of fluorothreonine and fluoroacetic acid by the thienamycin producer, Streptomyces cattleya

M Sanada, T Miyano, S Iwadare, J M Williamson, B H Arison, J L Smith, A W Douglas, J M Liesch, E Inamine
Free article

Biosynthesis of fluorothreonine and fluoroacetic acid by the thienamycin producer, Streptomyces cattleya

M Sanada et al. J Antibiot (Tokyo). 1986 Feb.
Free article

Abstract

An antimetabolite, THX, was isolated from fermentation broths of the thienamycin producer, Streptomyces cattleya, when the organism was grown in the presence of a fluorine-containing substrate. THX was subsequently identified as one of the four possible stereoisomers of 4-fluorothreonine. Inorganic fluoride or any one of a number of organofluorine compounds can be used as precursors of 4-fluorothreonine. In addition, 19F NMR has provided evidence that the organism synthesizes fluoroacetate under the same fermentation conditions. The in vitro antibacterial spectrum of 4-fluorothreonine is also presented.

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