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. 1986 Feb;8(1):49-54.

Estimation of human fetal-placental unit metabolic rate by application of the Bohr principle

D R Bonds, L O Crosby, T G Cheek, M Hägerdal, B B Gutsche, S G Gabbe
  • PMID: 3082967

Estimation of human fetal-placental unit metabolic rate by application of the Bohr principle

D R Bonds et al. J Dev Physiol. 1986 Feb.

Abstract

The Bohr Principle via continuous indirect calorimetry was used to estimate human fetal-placental unit metabolic rate in 12 normal women undergoing elective caesarean section under continuous lumbar epidural anaesthesia. Maternal oxygen consumption decreased after umbilical cord clamping and after placental removal. Fetal-placental unit oxygen consumption was 10.7 +/- 1.3 ml/min per kg (mean +/- SEM). Fetal oxygen consumption was 6.8 +/- 1.4 ml/min per kg. Placental oxygen consumption was 37 +/- 12 ml/min per kg. Fetal-placental unit carbon dioxide production was 9.2 +/- 1.2 ml/min per kg. These mean values agree favourably with measurements of uterine and fetal metabolism from other mammalian species. Maternal minute ventilation decreased with removal of the fetal-placental unit, and this decrease was found to be linearly related to the fetal-placental unit carbon dioxide production.

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