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. 2020 Mar;42(2):e121-e124.
doi: 10.1097/MPH.0000000000001444.

QT Interval Prolongation in the Pediatric Oncologic Population on Methadone

Jenna A Piccininni  1 , James S Killinger  2   3   4 , Hoda T Hammad  5 , Linda M Gerber  5 , Jeffrey D Dayton  2   6   4
Affiliations

QT Interval Prolongation in the Pediatric Oncologic Population on Methadone

Jenna A Piccininni et al. J Pediatr Hematol Oncol. 2020 Mar.

Abstract

Studies have been conducted on adults prescribed with methadone to determine the necessary frequency of QTc monitoring but no consensus has been reached and no similar research has been conducted in the pediatric population. The objective of this retrospective study was to determine the occurrence rate of QTc interval prolongation associated with methadone use in a pediatric oncologic population. In total, 18% of patients developed QTc interval prolongation. These patients had longer baseline QTc intervals and were on more QTc interval-prolonging medications. Our data suggest that these variables may be able to risk stratify patients who require more frequent monitoring.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1.
FIGURE 1.
Comparison of number of additional QTc interval-prolonging medications between patients who developed QTc interval prolongation and those who did not.
FIGURE 2.
FIGURE 2.
Comparison of baseline QTc intervals between patients who developed QTc interval prolongation and those who did not.
See this image and copyright information in PMC

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