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Review
. 2019 Jan 30;90(3-S):30-35.
doi: 10.23750/abm.v90i3-S.8172.

Drug-induced anaphylaxis in children

Fabio Cardinale  1 , Doriana Amato, Maria Felicia Mastrototaro, Carlo Caffarelli, Giuseppe Crisafulli, Fabrizio Franceschini, Lucia Liotti, Silvia Caimmi, Paolo Bottau, Francesca Saretta, Francesca Mori, Roberto Bernardini
Affiliations
Review

Drug-induced anaphylaxis in children

Fabio Cardinale et al. Acta Biomed. .

Abstract

Anaphylaxis represents one of the most frequent medical emergencies in childhood. However, as compared to adults, drugs are less common triggers of anaphylaxis in children, with a frequency which is increasing from infancy to adolescence. Deaths seldom occur, maybe because of the paucity of comorbidities in children. Antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) are the main elicitors in drug-induced anaphylaxis in children. Both immune-mediated (mainly IgE-mediated) and non immune-mediated may be involved. IgG-mediated and complement-mediated mechanisms has been also hypothesized. Correct management relies on a right diagnosis and prompt therapy. A proper work-up is also important to prevent further potentially fatal re-exposures to the same drug or other structurally similar molecules but also unnecessary avoidance of medications not representing the culprit of the episode.

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