Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jan 28;90(3-S):44-51.
doi: 10.23750/abm.v90i3-S.8160.

Mechanisms of hypersensitivity reactions induced by drugs

Fabrizio Franceschini  1 , Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Giuseppe Crisafulli, Lucia Liotti, Francesca Saretta, Roberto Bernardini, Francesca Mori, Carlo Caffarelli
Affiliations
Review

Mechanisms of hypersensitivity reactions induced by drugs

Fabrizio Franceschini et al. Acta Biomed. .

Abstract

Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated or non-immunologically mediated. The high number of DHRs unconfirmed and/or self-reported is a frequent problem in daily clinical practice, with considerable impact on future prescription choices and patient health. It is important to distinguish between hypersensitivity and non-hypersensitivity reactions by adopting a structured diagnostic approach to confirm or discard the suspected drug, not only to avoid life-threatening reactions, but also to reduce the frequent over-diagnosis of DHRs.

PubMed Disclaimer

References

    1. Macy E, Romano A, Khan DJ. Practical Management of Antibiotic Hypersensitivity in 2017. Allergy Clin Immunol Pract. 2017;5:577–86. - PubMed
    1. Gomes ER, Brockow K, Kuyucu S, Saretta F, Mori F, Blanca-Lopez N, et al. ENDA/EAACI Drug Allergy Interest Group. Drug hypersensitivity in children: report from the pediatric task force of the EAACI Drug Allergy Interest Group. Allergy. 2016;71:149–61. - PubMed
    1. Chiaverini Ensina LF, Lopes Amigo MH, Koch T, Guzman E, Paoli R, Camelo Nunes IC. Drug hypersensitivity in students from Sao Paulo, Brazil. Clinics. 2010;65:1009–11. - PMC - PubMed
    1. Harandian F, Pham D, Ben-Shoshan M. Positive penicillin allergy testing results: a system-atic review and meta-analysis of papers pub-lished from 2010 through 2015. Postgrad Med. 2016;128:557–62. - PubMed
    1. Rebelo Gomes E, Fonseca J, Araujo L, Demoly P. Drug allergy claims in children: from self-reporting to confirmed diagnosis. Clin Exp Allergy. 2008;38:191–98. - PubMed