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. 2019 Mar 1;20(5):1075.
doi: 10.3390/ijms20051075.

Assessment of the Efficacy of Platelet-Rich Plasma in the Treatment of Traumatic Canine Fractures

Sergio López  1 , José M Vilar  2 , Joaquín J Sopena  3   4 , Elena Damià  5 , Deborah Chicharro  6 , José M Carrillo  7   8 , Belén Cuervo  9 , And Mónica Rubio  10   11
Affiliations

Assessment of the Efficacy of Platelet-Rich Plasma in the Treatment of Traumatic Canine Fractures

Sergio López et al. Int J Mol Sci. .

Abstract

The role of platelet-rich plasma (PRP) in promoting the healing of bone fractures has not yet been clearly stated. The aim of this prospective clinical study was to evaluate the effectiveness of plasma rich in growth factors (PRGF, a PRP derivate) in the treatment of naturally-occurring bone fractures in dogs. With this objective, sixty-five dogs with radius/ulna or tibia/fibula bone fractures were randomly divided into two groups (PRGF and saline solution (SS) groups) and checked at days 0, 7, 14, 21, 28, 35, 42, 49, 56, 60, 63, 70, 120, and 180. All the fractures were treated with an external skeletal fixation, and pain was controlled with Carprofen. Healing was evaluated by physical examination, limb function, radiography, and by a Likert-type owner satisfaction questionnaire. A faster fracture healing was observed in the PRGF group, with statistically significant differences with respect to the SS group. Swelling at the fracture site was significantly greater at day 14 and 28 in animals injected with PRGF, and more pain on palpation was found in the area at day 28. The injection of PRGF in acute bone fractures accelerates bone healing.

Keywords: Carprofen; PRGF; bone healing; dog; fracture.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Boxplot corresponding to the days of implant removal for both PRGF and SS groups. Mean time was significantly higher in the SS group.
See this image and copyright information in PMC

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