Biomarkers and Imaging: Complementary or Subtractive?

Andrea Salzano¹, Alberto M Marra², Roberta D'Assante², Michele Arcopinto³, Eduardo Bossone⁴, Toru Suzuki⁵, Antonio Cittadini⁶

Affiliations

¹ Department of Cardiovascular Sciences, NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK; Department of Translational Medical Sciences, Federico II University, Via Pansini 5, Naples 80138, Italy.
² IRCCS SDN, Naples, Italy.
³ Emergency Department, A Cardarelli Hospital, Via Cardarelli 9, Naples 80131, Italy.
⁴ Cardiology Division, A Cardarelli Hospital, Via Cardarelli 9, Naples 80131, Italy.
⁵ Department of Cardiovascular Sciences, NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
⁶ Department of Translational Medical Sciences, Federico II University, Via Pansini 5, Naples 80138, Italy; Interdisciplinary Research Centre in Biomedical Materials (CRIB), Piazzale Tecchio 80, Naples 80125, Italy. Electronic address: antonio.cittadini@unina.it.

PMID: 30832821
DOI: 10.1016/j.hfc.2018.12.008

Review

Biomarkers and Imaging: Complementary or Subtractive?

Andrea Salzano et al. Heart Fail Clin. 2019 Apr.

. 2019 Apr;15(2):321-331.

doi: 10.1016/j.hfc.2018.12.008. Epub 2019 Feb 2.

Authors

Andrea Salzano¹, Alberto M Marra², Roberta D'Assante², Michele Arcopinto³, Eduardo Bossone⁴, Toru Suzuki⁵, Antonio Cittadini⁶

Affiliations

¹ Department of Cardiovascular Sciences, NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK; Department of Translational Medical Sciences, Federico II University, Via Pansini 5, Naples 80138, Italy.
² IRCCS SDN, Naples, Italy.
³ Emergency Department, A Cardarelli Hospital, Via Cardarelli 9, Naples 80131, Italy.
⁴ Cardiology Division, A Cardarelli Hospital, Via Cardarelli 9, Naples 80131, Italy.
⁵ Department of Cardiovascular Sciences, NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
⁶ Department of Translational Medical Sciences, Federico II University, Via Pansini 5, Naples 80138, Italy; Interdisciplinary Research Centre in Biomedical Materials (CRIB), Piazzale Tecchio 80, Naples 80125, Italy. Electronic address: antonio.cittadini@unina.it.

PMID: 30832821
DOI: 10.1016/j.hfc.2018.12.008

Abstract

Heart failure is a life-threatening disease. Its prevalence is characterized by a slow, steady increase, with unacceptable high mortality. Slowing disease progression is imperative. One of the most active field is the development of novel biomarkers. Biomarkers are used in routine clinical care for diagnosis, monitoring (response to treatment), and risk stratification of patients with heart failure. In this review, we consider in 2 different sections: blood-derived and imaging biomarkers. Finally, we analyze the effect of combining these 2 categories of biomarkers available in heart failure, aiming at understanding whether their role is complementary or subtractive.

Keywords: Biomarkers; Cardiovascular disease; Heart failure; Imaging; Prognosis.

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Biomarkers and Imaging: Complementary or Subtractive?

Affiliations

Biomarkers and Imaging: Complementary or Subtractive?

Authors

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Medical