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Review
. 2019 Mar 15;39(3):BSR20181377.
doi: 10.1042/BSR20181377. Print 2019 Mar 29.

The role of miRNAs in the invasion and metastasis of cervical cancer

Jin-Yan Wang  1   2 , Li-Juan Chen  3
Affiliations
Review

The role of miRNAs in the invasion and metastasis of cervical cancer

Jin-Yan Wang et al. Biosci Rep. .

Abstract

Cervical cancer (CC) with early metastasis of the primary tumor results in poor prognosis and poor therapeutic outcomes. MicroRNAs (miRNAs) are small, noncoding RNA molecules that play a substantial role in regulating gene expression post-transcriptionally and influence the development and progression of tumors. Numerous studies have discovered that miRNAs play significant roles in the invasion and metastasis of CC by affecting specific pathways, including Notch, Wnt/β-catenin, and phosphoinositide-3 kinase (PI3K)-Akt pathways. miRNAs also effectively modulate the process of epithelial-mesenchymal transition. Many studies provide new insights into the role of miRNAs and the pathogenesis of metastatic CC. In this review, we will offer an overview and update of our present understanding of the potential roles of miRNAs in metastatic CC.

Keywords: MicroRNAs; cervical cancer; invasion; metastasis.

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Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1
Figure 1. Oncogenic miRNAs and their targets in promoting metastasis
Figure 2
Figure 2. Oncosuppressor miRNAs and their targets in inhibiting metastasis
Figure 3
Figure 3. EMT-related miRNAs target TGF-β R2, Smad7, E-cadherin, N-cadherin, vimentin, Snail2, and FoxG1, and advance CC migration, invasion, and metastasis
Figure 4
Figure 4. EMT-related miRNAs inhibit CC migration, invasion, and metastasis by targetting ZEB1/2, Smad3, AEG-1, TCF7 L2, MUC4, SPARC, Wnt/β-catenin, SIP1, SFMBT, Bcl-2, Bax, NF-κB, E-cadherin, α-cadherin, Notch1, Jagged1, TCF-12, EphB2, Vimentin, MMP-9, STAT3, FZD7, Snail, FOMX1, BMI1, and EphA3
Figure 5
Figure 5. HPV-related miRNAs regulate CC migration, invasion, and metastasis by targetting PPARγ, TIMP2, DCUN1D1, and SFMBT1
See this image and copyright information in PMC

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