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. 2019 Jul;33(7):1140-1144.
doi: 10.1038/s41433-019-0388-0. Epub 2019 Mar 4.

Systemic oxidative stress in non-arteritic anterior ischemic optic neuropathy

Serife Birer  1 , Hatice Arda  2 , Deniz Kilic  3 , Gulden Baskol  4
Affiliations

Systemic oxidative stress in non-arteritic anterior ischemic optic neuropathy

Serife Birer et al. Eye (Lond). 2019 Jul.

Abstract

Purpose: To investigate whether the serum total oxidant status (TOS), total antioxidant status (TAS), advanced oxidation protein products (AOPP), and thiol parameters could play a role in the pathogenesis of non-arteritic anterior ischemic optic neuropathy (NA-AION).

Methods: In this study, 18 newly diagnosed NA-AION patients and 17 healthy subjects (control group) were included. Serum plasma TOS and TAS, AOPP, and thiol parameters were measured by spectrophotometric method and the results were compared.

Results: Mean age of the patients and the controls were 60.8 ± 8.4 and 61.9 ± 9.4 years, respectively (p = 0.729). There were no significant differences between the patients and the control group with regard to the values of TAS, TOS, AOPP, and thiol (p = 0.869, p = 0.863, p = 0.040, p = 0.314; respectively). There was a positive correlation between TOS and thiol (p = 0.002, r = 0.681).

Conclusion: We found no significant relationship between systemic oxidative parameters and NA-AION. However, this study should be accepted as a pilot investigation and needs to be validated.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Advanced oxidation protein productvalues
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References

    1. Rucker JC, Biousse V, Newman NJ. Ischemic optic neuropathies. Curr Opin Neurol. 2004;17:27–35. doi: 10.1097/00019052-200402000-00006. - DOI - PubMed
    1. Hattenhauer MG, Leavitt JA, Hodge DO, Grill R, Gray DT. Incidence of nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol. 1997;123:103–7. doi: 10.1016/S0002-9394(14)70999-7. - DOI - PubMed
    1. Johnson LN, Arnold AC. Incidence of nonarteritic and arteritic anterior ischemic optic neuropathy. Population-based study in the state of Missouri and Los Angeles County, California. J Neuroophthalmol. 1994;14:38–44. doi: 10.1097/00041327-199403000-00011. - DOI - PubMed
    1. Buono LM, Foroozan R, Sergott RC, Savino PJ. Nonarteritic anterior ischemic optic neuropathy. Curr Opin Ophthalmol. 2002;13:357–61. doi: 10.1097/00055735-200212000-00003. - DOI - PubMed
    1. Newman NJ, Scherer R, Langenberg P, Kelman S, Feldon S, Kaufman D, et al. The fellow eye in NAION: report from the ischemic optic neuropathy decompression trial follow-up study. Am J Ophthalmol. 2002;134:317–28. doi: 10.1016/S0002-9394(02)01639-2. - DOI - PubMed

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