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Review
. 2019 Feb 28;25(8):909-922.
doi: 10.3748/wjg.v25.i8.909.

Outcomes of per oral endoscopic pyloromyotomy in gastroparesis worldwide

Parit Mekaroonkamol  1 , Rushikesh Shah  1 , Qiang Cai  2
Affiliations
Review

Outcomes of per oral endoscopic pyloromyotomy in gastroparesis worldwide

Parit Mekaroonkamol et al. World J Gastroenterol. .

Abstract

Per oral endoscopic pyloromyotomy (POP), also known as gastric per-oral endoscopic myotomy (GPOEM), is a novel procedure with promising potential for the treatment of gastroparesis. As more data emerge and the procedure is becoming more recognized in clinical practice, its safety and efficacy need to be carefully evaluated. Appropriate patient selection for favorable clinical success prediction after GPOEM also needs additional research. This review aims to systemically summarize the existing data on clinical outcomes of POP. Symptomatologic responses to the procedure, its adverse effects, procedural techniques, and predictive factors of clinical success are also discussed.

Keywords: Gastric per-oral endoscopic myotomy; Gastroparesis; Outcomes; Per oral endoscopic pyloromyotomy; Pyloromyotomy.

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Conflict of interest statement

Conflict-of-interest statement: All the Authors have no conflict of interest related to the manuscript.

Figures

Figure 1
Figure 1
The procedural steps of per oral endoscopic pyloromyotomy. A: Pre-pyloric area in the stomach; B: Mucosotomy site in prepyloric area; C: Submucosal tunnel creation; D: Pyloric ring; E: Myotomy; F: Closure of mucosotomy site with endoclips.
See this image and copyright information in PMC

References

    1. Wang YR, Fisher RS, Parkman HP. Gastroparesis-related hospitalizations in the United States: Trends, characteristics, and outcomes, 1995-2004. Am J Gastroenterol. 2008;103:313–322. - PubMed
    1. Gonzalez JM, Benezech A, Vitton V, Barthet M. G-POEM with antro-pyloromyotomy for the treatment of refractory gastroparesis: Mid-term follow-up and factors predicting outcome. Aliment Pharmacol Ther. 2017;46:364–370. - PubMed
    1. Parkman HP, Camilleri M, Farrugia G, McCallum RW, Bharucha AE, Mayer EA, Tack JF, Spiller R, Horowitz M, Vinik AI, Galligan JJ, Pasricha PJ, Kuo B, Szarka LA, Marciani L, Jones K, Parrish CR, Sandroni P, Abell T, Ordog T, Hasler W, Koch KL, Sanders K, Norton NJ, Hamilton F. Gastroparesis and functional dyspepsia: Excerpts from the AGA/ANMS meeting. Neurogastroenterol Motil. 2010;22:113–133. - PMC - PubMed
    1. Lacy BE, Crowell MD, Mathis C, Bauer D, Heinberg LJ. Gastroparesis: Quality of Life and Health Care Utilization. J Clin Gastroenterol. 2018;52:20–24. - PubMed
    1. Parkman HP, Hasler WL, Fisher RS American Gastroenterological Association. American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis. Gastroenterology. 2004;127:1592–1622. - PubMed