Endodontic biofilms: contemporary and future treatment options

Yeon-Jee Yoo¹, Hiran Perinpanayagam², Soram Oh³, A-Reum Kim⁴, Seung-Hyun Han⁴, Kee-Yeon Kum¹

Affiliations

¹ Department of Conservative Dentistry, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
² Division of Restorative Dentistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada.
³ Department of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seoul, Korea.
⁴ Department of Oral Microbiology and Immunology, Dental Research Institute and BK21 Plus Program, School of Dentistry, Seoul National University, Seoul, Korea.

PMID: 30834229
PMCID: PMC6387897
DOI: 10.5395/rde.2019.44.e7

Review

Endodontic biofilms: contemporary and future treatment options

Yeon-Jee Yoo et al. Restor Dent Endod. 2019.

. 2019 Jan 31;44(1):e7.

doi: 10.5395/rde.2019.44.e7. eCollection 2019 Feb.

Authors

Yeon-Jee Yoo¹, Hiran Perinpanayagam², Soram Oh³, A-Reum Kim⁴, Seung-Hyun Han⁴, Kee-Yeon Kum¹

Affiliations

¹ Department of Conservative Dentistry, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
² Division of Restorative Dentistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada.
³ Department of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seoul, Korea.
⁴ Department of Oral Microbiology and Immunology, Dental Research Institute and BK21 Plus Program, School of Dentistry, Seoul National University, Seoul, Korea.

PMID: 30834229
PMCID: PMC6387897
DOI: 10.5395/rde.2019.44.e7

Abstract

Apical periodontitis is a biofilm-mediated infection. The biofilm protects bacteria from host defenses and increase their resistance to intracanal disinfecting protocols. Understanding the virulence of these endodontic microbiota within biofilm is essential for the development of novel therapeutic procedures for intracanal disinfection. Both the disruption of biofilms and the killing of their bacteria are necessary to effectively treat apical periodontitis. Accordingly, a review of endodontic biofilm types, antimicrobial resistance mechanisms, and current and future therapeutic procedures for endodontic biofilm is provided.

Keywords: Antimicrobial resistance; Endodontic biofilm; Intracanal disinfection; Lactobacillus; Lipoteichoic acid.

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Conflict of interest statement

Conflict of Interest: No potential conflict of interest relevant to this article was reported.

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Endodontic biofilms: contemporary and future treatment options

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Endodontic biofilms: contemporary and future treatment options

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