Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Aug:57:134-140.
doi: 10.1016/j.conb.2019.01.014. Epub 2019 Mar 2.

Neural populations for maintaining body fluid balance

Takako Ichiki  1 , Vineet Augustine  1 , Yuki Oka  2
Affiliations
Review

Neural populations for maintaining body fluid balance

Takako Ichiki et al. Curr Opin Neurobiol. 2019 Aug.

Abstract

Fine balance between loss-of water and gain-of water is essential for maintaining body fluid homeostasis. The development of neural manipulation and mapping tools has opened up new avenues to dissect the neural circuits underlying body fluid regulation. Recent studies have identified several nodes in the brain that positively and negatively regulate thirst. The next step forward would be to elucidate how neural populations interact with each other to control drinking behavior.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement

Nothing declared.

Figures

Figure 1
Figure 1
Flow chart of the inhibitory effects on the SFO thirst driving neurons. After ingestion, the MnPOGLP1r neurons quickly respond to drinking of any types of liquid, and provide transient inhibition to the SFOnNOS neurons. It remains unknown which neurons are specifically activated by hypo-osmolarity induced by water ingestion and send the persistent inhibitory signal to the SFO.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Fitzsimons JT: Angiotensin, thirst, and sodium appetite. Physiol Rev 1998, 78:583–686. - PubMed
    1. Setler P: Drinking induced by injection of angiotensin II into the hypothalamus of the rhesus monkey. J Physiol 1971, 217:59P–60P. - PubMed
    1. Sharpe LG, Swanson LW: Drinking induced by injections of angiotensin into forebrain and mid-brain sites of the monkey. J Physiol 1974, 239:595–622. - PMC - PubMed
    1. Simonnet G, Rodriguez F, Fumoux F, Czernichow P, Vincent JD: Vasopressin release and drinking induced by intracranial injection of angiotensin II in monkey. Am J Physiol 1979, 237: R20–R25. - PubMed
    1. Andersson B, Westbye O: Synergistic action of sodium and angiotensin on brain mechanisms controlling water and salt balance. Nature 1970, 228:75. - PubMed

Publication types