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Review
. 2019 Mar 4;24(5):899.
doi: 10.3390/molecules24050899.

Dietary Phytochemicals Targeting Cancer Stem Cells

Alena Liskova  1 , Peter Kubatka  2 , Marek Samec  3 , Pavol Zubor  4 , Milos Mlyncek  5 , Tibor Bielik  6 , Samson Mathews Samuel  7 , Anthony Zulli  8 , Taeg Kyu Kwon  9 , Dietrich Büsselberg  10
Affiliations
Review

Dietary Phytochemicals Targeting Cancer Stem Cells

Alena Liskova et al. Molecules. .

Abstract

There is an increasing awareness of the importance of a diet rich in fruits and vegetables for human health. Cancer stem cells (CSCs) are characterized as a subpopulation of cancer cells with aberrant regulation of self-renewal, proliferation or apoptosis leading to cancer progression, invasiveness, metastasis formation, and therapy resistance. Anticancer effects of phytochemicals are also directed to target CSCs. Here we provide a comprehensive review of dietary phytochemicals targeting CSCs. Moreover, we evaluate and summarize studies dealing with effects of dietary phytochemicals on CSCs of various malignancies in preclinical and clinical research. Dietary phytochemicals have a significant impact on CSCs which may be applied in cancer prevention and treatment. However, anticancer effects of plant derived compounds have not yet been fully investigated in clinical research.

Keywords: cancer stem cells; cell signaling; fruit; phytochemicals; plant-derived foods; vegetable.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Association between surface markers and promotion of CSCs stem-like properties [3,20,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41].
Figure 2
Figure 2
Mechanisms involved in stem-like maintenance and death resistance of CSCs.
Figure 3
Figure 3
Dietary phytochemicals targeting CSCs in preclinical and clinical cancer research.
See this image and copyright information in PMC

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