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Comment
. 2019 May 15;25(10):2943-2945.
doi: 10.1158/1078-0432.CCR-19-0188. Epub 2019 Mar 5.

Tumor Landscapes: β-Catenin Drives Immune Desertification

Denarda Dangaj #  1 , David Barras #  1 , George Coukos  2
Affiliations
Comment

Tumor Landscapes: β-Catenin Drives Immune Desertification

Denarda Dangaj et al. Clin Cancer Res. .

Abstract

Immune checkpoint blockade therapy requires a preestablished activated immune landscape. Understanding tumor-intrinsic mechanisms that lead to T-cell desertification is key to resensitizing them to such therapies. The WNT/β-catenin tumor-intrinsic signaling is emerging as an immune exclusion pathway that holds high promise to counteract resistance to immunotherapy.See related article by Luke et al., p. 3074.

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