Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Feb 1;13(1):89-99.
doi: 10.1302/1863-2548.13.180109.

Chondrosarcoma in a paediatric population: a study of 247 cases

A-M Wu  1 , G Li  2 , J-W Zheng  3 , C-H Chen  1 , D Chen  1 , Z-G Qiao  4 , J-G Zhao  5 , B Wang  6 , W-L Fu  7 , S-R Sheng  1 , Y-S Wu  1 , N-F Tian  1 , Z-K Lin  1 , H Xu  1
Affiliations

Chondrosarcoma in a paediatric population: a study of 247 cases

A-M Wu et al. J Child Orthop. .

Abstract

Purpose: The aims of present study are to clarify the follow questions: 1) what constitutes paediatric chondrosarcoma?; 2) what are the effects of the demographic and tumour characteristics on survival in patients with paediatric chondrosarcoma?; 3) which prognostic factors of paediatric chondrosarcoma differ from those of the adult population, which have been reported previously?

Methods: Paediatric patients who were diagnosed with chondrosarcoma were searched for using the case listing session protocol of the National Cancer Institute's Surveillance, Epidemiology, and End Results 18 databases (1973 to 2014). The extracted demographic information includes: age, race, gender, year of diagnosis, tumour sites, tumour histological subtype, grade, stage and treatment.

Results: A total of 247 paediatric chondrosarcoma patients were extracted and included in our present study. We find that the paediatric patients have significantly better survival rates than the adult patients. The year of diagnosis, tumour sites, tumour histological subtype, grade, stage and surgery received are independent prognostic factors for the survival rate of paediatric chondrosarcoma patients, but race, gender and age are not.

Conclusion: The paediatric chondrosarcoma patients have better survival rates than the adults. Paediatric patients with a diagnosis at an early age, tumour site at the vertebral column and pelvis/sacrococcyx, myxoid variants, high grade, distant stage and who did not have surgery have a poorer prognosis than patients with a diagnosis at a later age, tumour site at limbs, head and base, chondrosarcoma not otherwise specified, lower grade, localized stage and who received surgery.

Level of evidence: II -Prognostic Study.

Keywords: chondrosarcoma; paediatric; prognosis; survival.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Kaplan-Meier survival curves illustrating the chondrosarcoma cancer-specific survival (a) and overall survival (b) between paediatric and adult patients.
Fig. 2
Fig. 2
Kaplan-Meier survival curves illustrating the chondrosarcoma cancer-specific survival (a) and overall survival (b) among different categories of year of diagnosis.
Fig. 3
Fig. 3
Kaplan-Meier survival curves illustrating the chondrosarcoma cancer-specific survival (a) and overall survival (b) among different tumour sites.
Fig. 4
Fig. 4
The summarized number of histological subtypes in each age categories and the surgical ratio of each histological subtype (NOS, not otherwise specified).
Fig. 5
Fig. 5
Kaplan-Meier survival curves illustrating the chondrosarcoma cancer-specific survival (a) and overall survival (b) among different histological subtypes (NOS, not otherwise specified).
Fig. 6
Fig. 6
Kaplan-Meier survival curves illustrating the chondrosarcoma cancer-specific survival (a) and overall survival (b) among different grades (GradeX, unknown grade).
Fig. 7
Fig. 7
Kaplan-Meier survival curves illustrating the chondrosarcoma cancer-specific survival (a) and overall survival (b) among different stages (StageX, unknown stage).
Fig. 8
Fig. 8
Kaplan-Meier survival curves illustrating the chondrosarcoma cancer-specific survival (a) and overall survival (b) between patients with or without surgery.
See this image and copyright information in PMC

References

    1. Gelderblom H, Hogendoorn PC, Dijkstra SD, et al. . The clinical approach towards chondrosarcoma. Oncologist 2008;13:320-329. - PubMed
    1. Sundaresan N, Rosen G, Boriani S. Primary malignant tumors of the spine. Orthop Clin North Am 2009;40:21-36. - PubMed
    1. Arshi A, Sharim J, Park DY, et al. . Chondrosarcoma of the osseous spine: an analysis of epidemiology, patient outcomes, and prognostic factors using the SEER Registry from 1973 to 2012. Spine 2017;42:644-652. - PMC - PubMed
    1. Strike SA, McCarthy EF. Chondrosarcoma of the spine: a series of 16 cases and a review of the literature. Iowa Orthop J 2011;31:154-159. - PMC - PubMed
    1. Giuffrida AY, Burgueno JE, Koniaris LG, et al. . Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database. J Bone Joint Surg [Am] 2009;91-A:1063-1072. - PubMed