Corrigendum: Controlled Human Infections As a Tool to Reduce Uncertainty in Clinical Vaccine Development

Abstract

[This corrects the article DOI: 10.3389/fmed.2018.00297.].

Keywords: clinical development; low-income access; malaria; product development (PD) process; vaccine.

Figure 2

Decision tree showing the optimal order of questions to generate the highest project value, given estimated probability of success (PoS) and costs (million euro, €M) per scientific question. In the case PoS and costs for every question are equal, the order does not matter for the project value (A), however unequal distributions will clearly show different project values for the optimal order in blue, second best order in red and user defined order in green (B). A 1 €M additional investment in “correlates” has a major effect on the optimal order and project value (C).