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. 2019 Apr;10(2):725-734.
doi: 10.1007/s13300-019-0589-3. Epub 2019 Mar 5.

The Association Between Trimester-Specific Weight Gain and Severe Preeclampsia/Adverse Perinatal Outcome in Gestational Diabetes Mellitus Complicated by Preeclampsia: A Retrospective Case Study

Xueqin Zhang  1 , Yunshan Xiao  2
Affiliations

The Association Between Trimester-Specific Weight Gain and Severe Preeclampsia/Adverse Perinatal Outcome in Gestational Diabetes Mellitus Complicated by Preeclampsia: A Retrospective Case Study

Xueqin Zhang et al. Diabetes Ther. 2019 Apr.

Abstract

Introduction: Gestational diabetes mellitus (GDM) and preeclampsia share many risk factors, e.g., gestational weight gain (GWG). Previous studies on the co-occurrence of these two diseases cannot powerfully clear up the effects of GWG on perinatal outcome.

Methods: A total of 329 pregnant women with GDM complicated by preeclampsia were enrolled. Clinical data of mothers and newborns were retrospectively analyzed, including baseline characteristics of pregnant women and pregnancy outcomes. We focused on the association between trimester-specific weight gain and severe preeclampsia (s-PE)/adverse perinatal outcomes in GDM complicated by preeclampsia, including cesarean section (C-sect), preterm birth, and large for gestational age birth (LGA). Regression analysis was used to adjust the impact of confounding factors, including height, age, parity, scarred uterus, and so on.

Result: By unconditional regression analysis, middle trimester excessive GWG is a risk factor for LGA [OR 6.586, 95% CI (2.254-19.242), AOR 6.481, 95% CI (2.213-18.981)]; late excessive GWG is a risk factor for s-PE and C-sect [OR 1.683, 95% CI (1.084-2.614), AOR 1.888, 95% CI (1.193-2.990); and OR 1.754, 95% CI (1.121-2.744), AOR 1.841, 95% CI (1.153-2.937)], excessive total GWG is a risk factor for LGA, and is a protective factor for the preterm [OR 5.920, 95% CI (2.479-14.139), AOR 5.602, 95% CI (2.337-13.431); and OR 0.448, 95% CI (0.248-0.841), AOR 0.429, 95% CI (0.235-0.783)].

Conclusions: The trimester-specific weight gain has a significant impact on the perinatal outcomes among pregnant women with both GDM and preeclampsia. This study is helpful for carry out risk monitoring in time, identifying early warning signs, and improving maternal and infant health.

Keywords: Gestational diabetes mellitus; Perinatal outcome; Preeclampsia; Trimester-specific weight gain.

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References

    1. Mirghani Dirar A, Doupis J. Gestational diabetes from A to Z. World J Diabetes. 2017;8(12):489–511. doi: 10.4239/wjd.v8.i12.489. - DOI - PMC - PubMed
    1. Mosca L, Benjamin EJ, Berra K, et al. Effectiveness-based guidelines for the prevention of cardiovascular disease in women-2011 update: a guideline from the American Heart Association. J Am Coll Cardiol. 2011;57(12):1404–1423. doi: 10.1016/j.jacc.2011.02.005. - DOI - PMC - PubMed
    1. Roberts JM, Lain KY. Recent Insights into the pathogenesis of pre-eclampsia. Placenta. 2002;23(5):359–372. doi: 10.1053/plac.2002.0819. - DOI - PubMed
    1. Jin WY, Lin SL, Hou RL, et al. Associations between maternal lipid profile and pregnancy complicatisons and perinatal outcomes: a population-based study from China. BMC Pregnancy Childbirth. 2016;16:60. doi: 10.1186/s12884-016-0852-9. - DOI - PMC - PubMed
    1. Schneider S, Freerksen N, Rohrig S, Hoeft B, Maul H. Gestational diabetes and preeclampsia–similar risk factor profiles? Early Hum Dev. 2012;88(3):179–184. doi: 10.1016/j.earlhumdev.2011.08.004. - DOI - PubMed

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