Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2019 Jun;119(7):932-940.
doi: 10.1002/jso.25440. Epub 2019 Mar 5.

Adjuvant chemotherapy and outcomes in patients with nodal and resection margin-negative pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

Nicola Flaum  1 , Richard A Hubner  1 , Juan W Valle  1   2 , Eitan Amir  3 , Mairéad G McNamara  1   2
Affiliations
Meta-Analysis

Adjuvant chemotherapy and outcomes in patients with nodal and resection margin-negative pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

Nicola Flaum et al. J Surg Oncol. 2019 Jun.

Abstract

Adjuvant chemotherapy (AC) following pancreatic carcinoma (PC) resection improves overall survival (OS). A systematic review identified 10 phase-2/3 studies investigating AC in 3644 patients looking at the influence of nodal and resection status. AC significantly improved disease free survival, OS and 5-year odds of death risk. There was greater survival benefit in patients PS 0 and with body/tail tumors. There was a nonsignificant effect in N - /N + patients on OS and no difference between R0/R1 patients.

Keywords: adjuvant chemotherapy; lymph nodes; meta-analysis; pancreatic cancer; resection margin; systematic review.

PubMed Disclaimer

Comment in

MeSH terms

LinkOut - more resources