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. 2019:26:13.
doi: 10.1051/parasite/2019013. Epub 2019 Mar 6.

Congenital toxoplasmosis in the United States: clinical and serologic findings in infants born to mothers treated during pregnancy

Tudor Rares Olariu  1 , Cindy Press  2 , Jeanne Talucod  2 , Kjerstie Olson  2 , José Gilberto Montoya  3
Affiliations

Congenital toxoplasmosis in the United States: clinical and serologic findings in infants born to mothers treated during pregnancy

Tudor Rares Olariu et al. Parasite. 2019.

Abstract
in English, French

We assessed clinical and serologic findings in 25 infants with congenital toxoplasmosis born to mothers treated during pregnancy in the United States. Results indicate a lower prevalence of eye findings and hydrocephalus in the group of infants born to treated mothers (62.5% and 38.5%, respectively) compared to results on the same pathologies reported in our previous cohort of infants born to untreated mothers (92.2% and 67.7%, respectively). The sensitivity of the IgM ISAGA and IgA ELISA in the present study were lower (44% and 60%, respectively) compared to sensitivity of these methods in our previously studied group of infants born to untreated mothers (86.6% and 76.5%, respectively). These findings provide further evidence that anti-parasitic treatment if administered during pregnancy can contribute to better clinical outcomes, even in countries where systematic screening and treatment have not been routinely implemented.

Nous avons évalué les résultats cliniques et sérologiques chez 25 nourrissons atteints de toxoplasmose congénitale, nés de mères traitées pendant la grossesse aux États-Unis. Les résultats indiquent une prévalence plus faible des lésions oculaires et de l’hydrocéphalie dans le groupe des nourrissons nés de mères traitées (62,5 % et 38,5 %, respectivement) par rapport aux résultats sur les même pathologies rapportés dans notre cohorte précédente de nourrissons nés de mères non traitées (respectivement 92,2 % et 67,7 %). La sensibilité des tests ISAGA IgM et ELISA IgA dans la présente étude était inférieure (44 % et 60 %, respectivement) par rapport à la sensibilité de ces méthodes dans notre groupe de nourrissons nés de mères non traitées (respectivement 86,6 % et 76,5 %). Ces résultats confirment également que le traitement antiparasitaire administré pendant la grossesse peut contribuer à améliorer les résultats cliniques, même dans les pays où le dépistage et le traitement systématiques n’ont pas été mis en œuvre de manière systématique.

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