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Review
. 2019 May 1;30(5):744-756.
doi: 10.1093/annonc/mdz084.

Head and neck cancer prevention: from primary prevention to impact of clinicians on reducing burden

D Hashim  1 , E Genden  2 , M Posner  3 , M Hashibe  4 , P Boffetta  3
Affiliations
Review

Head and neck cancer prevention: from primary prevention to impact of clinicians on reducing burden

D Hashim et al. Ann Oncol. .

Abstract

Survival from head and neck cancers (HNCs) of the lip, oral cavity, pharynx, and larynx has increased by 10% over the past few decades. Little over half of patients who develop HNCs will survive beyond 5 years. Survival is lower for individuals in many countries where traditional risk factors such as tobacco smoking, alcohol drinking, and betel quid chewing are highly prevalent but tertiary health care center access is limited or unavailable. Early diagnosis of HNC is the most important prognostic factor for each tumor site. Molecular-based research on HNC tumors holds promise for early stage detection, screening, vaccination, disease follow-up, and progression. Future investments for HNC control must consider both effectiveness and sustainability for both high- and low-resource countries alike, with priority toward risk factor prevention and earlier diagnosis.

Keywords: cancer prevention; dentists; early detection of cancer/statistics & numerical data; head and neck neoplasms; mouth neoplasms; mouth neoplasms/diagnosis.

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References

    1. Pai SI, Westra WH.. Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment. Annu Rev Pathol Mech Dis 2009; 4(1): 49–70. - PMC - PubMed
    1. Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence – SEER 9 Regs Research Data, Nov 2014 Sub (1973–2012) <Katrina/Rita Population Adjustment> – Linked To County Attributes – Total U.S., 1969–2013 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch, released April 2015, based on the November 2014 submission. 2015.
    1. Pruegsanusak K, Peeravut S, Leelamanit V. et al. Survival and prognostic factors of different sites of head and neck cancer: an analysis from Thailand. Asian Pac J Cancer Prev 2012; 13(3): 885–890. - PubMed
    1. Sinha R, Anderson DE, McDonald SS, Greenwald P.. Cancer risk and diet in India. J Postgrad Med 2003(Jul–Sep); 49(3): 222–228. - PubMed
    1. Nandakumar A, Nandakumar A.. Survival in head and neck cancers—results of a multi- institution study. Asian Pac J Cancer Prev 2016; 17(4): 1745–1754. - PubMed

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