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Review
. 2019 Sep 9;58(37):12761-12777.
doi: 10.1002/anie.201900932. Epub 2019 Jul 26.

IDPi Catalysis

Lucas Schreyer  1 , Roberta Properzi  1 , Benjamin List  1
Affiliations
Review

IDPi Catalysis

Lucas Schreyer et al. Angew Chem Int Ed Engl. .

Abstract

High acidity and structural confinement are pivotal elements in asymmetric acid catalysis. The recently introduced imidodiphosphorimidate (IDPi) Brønsted acids have met with remarkable success in combining those features, acting as powerful Brønsted acid catalysts and "silylium" Lewis acid precatalysts in numerous thus far inaccessible transformations. Substrates as challenging to activate as simple olefins were readily transformed, ketones were employed as acceptors in aldolizations allowing sub-ppm level catalysis, whereas enolates of the smallest donor aldehyde, acetaldehyde, did not polymerize but selectively added a single time to a variety of acceptor aldehydes.

Keywords: ACDC; Brønsted acids; Lewis acids; enantioselective catalysis; organocatalysis; silylium ions.

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References

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