Advancing Chemokine GPCR Structure Based Drug Discovery

Suwen Zhao¹, Beili Wu², Raymond C Stevens³

Affiliations

¹ iHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
² CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
³ iHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: stevens@shanghaitech.edu.cn.

PMID: 30840872
DOI: 10.1016/j.str.2019.02.004

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Advancing Chemokine GPCR Structure Based Drug Discovery

Suwen Zhao et al. Structure. 2019.

Free article

. 2019 Mar 5;27(3):405-408.

doi: 10.1016/j.str.2019.02.004.

Authors

Suwen Zhao¹, Beili Wu², Raymond C Stevens³

Affiliations

¹ iHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
² CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
³ iHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: stevens@shanghaitech.edu.cn.

PMID: 30840872
DOI: 10.1016/j.str.2019.02.004

Abstract

In this issue of Structure, Apel et al., (2019) provide structural insight into the inhibition of a human chemokine G-protein-coupled receptor by a small-molecule antagonist, which advances our understanding of drug design principles for this complex family of receptors.

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Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists.
Apel AK, Cheng RKY, Tautermann CS, Brauchle M, Huang CY, Pautsch A, Hennig M, Nar H, Schnapp G. Apel AK, et al. Structure. 2019 Mar 5;27(3):427-438.e5. doi: 10.1016/j.str.2018.10.027. Epub 2018 Dec 20. Structure. 2019. PMID: 30581043

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Advancing Chemokine GPCR Structure Based Drug Discovery

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Advancing Chemokine GPCR Structure Based Drug Discovery

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