Renal transplantation in light chain nephropathy: case report and review of the literature

Abstract

A successful cadaveric transplantation in a patient with irreversible renal insufficiency due to light chain nephropathy is reported. Remission of the monoclonal gammopathy was induced with melphalan and prednisone and after 4.5 years of hemodialysis a cadaveric kidney transplantation was performed, which resulted in excellent renal function up to 3.5 years after transplantation. Along with 8 previously reported patients in the literature this case demonstrates that renal transplantation can no longer be withheld from this category of patients, when they are in remission and no other major complications of their monoclonal gammopathy are present.