Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jun 30;38(2):205-211.
doi: 10.23876/j.krcp.18.0074.

Serum alkaline phosphatase and γ-glutamyl transferase in acute pyelonephritis

Chaehoon Han  1 , Young-Ki Lee  1 , Hayne Cho Park  1 , Ajin Cho  1 , Sun Ryoung Choi  1 , Jong-Woo Yoon  1 , Ja Ryong Koo  1 , Hyung Jik Kim  1 , Jung-Woo Noh  1 , Min-Jeong Park  2
Affiliations

Serum alkaline phosphatase and γ-glutamyl transferase in acute pyelonephritis

Chaehoon Han et al. Kidney Res Clin Pract. .

Abstract

Background: Elevated serum alkaline phosphatase (AP) and γ-glutamyl transferase (γ-GT) are commonly observed in patients with acute pyelonephritis. The goal of this study was to examine the clinical significance of elevated serum AP and γ-GT levels and to explore the mechanisms underlying these changes.

Methods: We examined serum AP and γ-GT levels in 438 patients with acute pyelonephritis. Urine AP/creatinine (Cr), urine γ-GT/Cr, fractional excretion of AP, and fractional excretion of γ-GT (FEγ-GT) were evaluated in patients with elevated and normal serum levels. AP isoenzymes were also examined.

Results: We identified 77 patients (17.6%) with elevated serum AP and 134 patients (30.6%) with elevated serum γ-GT. Among them, both enzymes were elevated in 64 patients (14.6%). Older age, longer hospital stay, elevated baseline serum Cr, and complicated pyelonephritis were associated with increases in serum AP and γ-GT. Multivariate analysis showed that high serum AP levels were significantly correlated with renal impairment (odds ratio, 2.13; 95% confidence interval, 1.08-4.19; P = 0.029). FEγ-GT was significantly lower in patients with elevated serum enzyme levels. The liver fraction for AP isoenzyme profile did not increase in patients with elevated serum AP.

Conclusion: Our results demonstrated that elevated serum AP and γ-GT levels are associated with complicated pyelonephritis and renal impairment. Lower FEγ-GT levels in patients with elevated serum enzymes may be the result of decreased urinary excretion of these enzymes.

Keywords: Alkaline phosphatase; Pyelonephritis; gamma-Glutamyltransferase.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest

All authors have no conflicts of interest to declare.

References

    1. Gault MH, Steiner G. Serum and urinary enzyme activity after renal infarction. Can Med Assoc J. 1965;93:1101–1105. - PMC - PubMed
    1. Atlas I, Kwan D, Stone N. Value of serum alkaline phosphatase and radionuclide bone scans in patients with renal cell carcinoma. Urology. 1991;38:220–222. doi: 10.1016/S0090-4295(91)80348-B. - DOI - PubMed
    1. Refaie MO, Abo-Zaid H, Gomma NA, Aboul-Enein HY. Determination of urinary and serum beta-glucuronidase and alkaline phosphatase in various renal disease and kidney rejection transplanted patients. Prep Biochem Biotechnol. 2000;30:93–106. doi: 10.1080/10826060008544949. - DOI - PubMed
    1. Salgó L, Szabó A. Gamma-glutamyl transpeptidase activity in human urine. Clin Chim Acta. 1982;126:9–16. doi: 10.1016/0009-8981(82)90357-6. - DOI - PubMed
    1. Fotino S. Elevation of serum alkaline phosphatase in severe pyelonephritis and obstructive nephropathy. Nephron. 1974;12:197–210. doi: 10.1159/000180376. - DOI - PubMed

LinkOut - more resources