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Multicenter Study
. 2019 May;42(5):524-529.
doi: 10.1002/clc.23171. Epub 2019 Mar 29.

Electrocardiographic findings in peripartum cardiomyopathy

Michael C Honigberg  1 , Uri Elkayam  2 , Navin Rajagopalan  3 , Kalgi Modi  4 , Joan E Briller  5 , Mark H Drazner  6 , Gretchen L Wells  3 , Dennis M McNamara  7 , Michael M Givertz  8 ; IPAC Investigators
Affiliations
Multicenter Study

Electrocardiographic findings in peripartum cardiomyopathy

Michael C Honigberg et al. Clin Cardiol. 2019 May.

Abstract

Background: There is limited data on electrocardiographic (ECG) abnormalities and their prognostic significance in women with peripartum cardiomyopathy (PPCM). We sought to characterize ECG findings in PPCM and explore the association of ECG findings with myocardial recovery and clinical outcomes.

Hypothesis: We hypothesized that ECG indicators of myocardial remodeling would portend worse systolic function and outcomes.

Methods: Standard 12-lead ECGs were obtained at enrollment in the Investigations of Pregnancy-Associated Cardiomyopathy study and analyzed for 88 women. Left ventricular ejection fraction (LVEF) was measured by echocardiography at baseline, 6 months, and 12 months. Women were followed for clinical events (death, mechanical circulatory support, and/or cardiac transplantation) until 1 year.

Results: Half of women had an "abnormal" ECG, defined as atrial abnormality, ventricular hypertrophy, ST-segment deviation, and/or bundle branch block. Women with left atrial abnormality (LAA) had lower LVEF at 6 months (44% vs 52%, P = 0.02) and 12 months (46% vs 54%, P = 0.03). LAA also predicted decreased event-free survival at 1 year (76% vs 97%, P = 0.008). Neither left ventricular hypertrophy by ECG nor T-wave abnormalities predicted outcomes. A normal ECG was associated with recovery in LVEF to ≥50% (84% vs 49%, P = 0.001) and event-free survival at 1 year (100% vs 85%, P = 0.01).

Conclusions: ECG abnormalities are common in women with PPCM, but a normal ECG does not rule out the presence of PPCM. LAA predicted lower likelihood of myocardial recovery and event-free survival, and a normal ECG predicted favorable event-free survival.

Keywords: electrocardiography; maternal-fetal health; outcomes; peripartum cardiomyopathy.

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Figures

Figure 1
Figure 1
(A) Survival free from mechanical circulatory support, cardiac transplantation, and/or death for women with and without left atrial abnormality (LAA) on electrocardiogram (ECG) at study enrollment. (B) Survival free from mechanical circulatory support, cardiac transplantation, and/or death for women with a “normal” ECG (no atrial abnormality, ventricular hypertrophy, ST‐segment deviation, or bundle branch block) or “abnormal” ECG at study enrollment
See this image and copyright information in PMC

References

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