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. 2019 Dec;34(1):783-788.
doi: 10.1080/14756366.2019.1587418.

Osteopontin - a biomarker of disease, but also of stage stratification of the functional myocardial contractile deficit by chronic ischaemic heart disease

Bogdan-Ioan Coculescu  1   2   3 , Gheorghe Manole  3   4 , Gabi Valeriu Dincă  1 , Elena Claudia Coculescu  5 , Cristina Berteanu  6 , Cristina Mariana Stocheci  7
Affiliations

Osteopontin - a biomarker of disease, but also of stage stratification of the functional myocardial contractile deficit by chronic ischaemic heart disease

Bogdan-Ioan Coculescu et al. J Enzyme Inhib Med Chem. 2019 Dec.

Abstract

The study analyses the significance of the plasmatic values of the OPN dosed to 91 people suffering from diastolic cardiac dysfunction with preserved ejection fraction, thus revealing significant growths of its level compared to the normal value. Despite being a clinical research, its conclusions are a breakthrough, differing from the results of other studies published in the relevant medical literature. We can make this assertion because this study analyses the clinical information given by the circulating values of the OPN, based on experimental models (animals), or on patients with congestive heart failure, which can be identified with the existence of a low systolic flow. The results of our study allow us to assert that the plasmatic values of this glycoprotein lead to its acceptance in the medical practice as a new biomarker that provides indicators regarding the stratification of risk with the patients suffering from heart failure of the diastolic dysfunction type, but whose systolic flow is preserved.

Keywords: Osteopontin (OPN); biomarker; diastolic heart failure (DHF); preserved ejection fraction.

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Figures

Figure 1.
Figure 1.
Communication between the interstitial matrix and cardiomyocytes, via activation of the integrin receptor. Activation of myocardial intra-fibrous synthesis pathways leading to myocardial remodelling and fibrosis.
Figure 2.
Figure 2.
Distribution of the study cases in relation to patients’ sex and age group.
Figure 3.
Figure 3.
Distribution of batch case size by classes of contractile deficit, using the NYHA classification criteria.
Figure 4.
Figure 4.
Comparison of the incidence of serum values of OPN in the batch, depending on the sex of the patients.
Figure 5.
Figure 5.
Comparison between the normal OPN serum values and the medium serum OPN concentration of the research sample.
See this image and copyright information in PMC

References

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