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Meta-Analysis
. 2019 Mar 7;14(3):e0213624.
doi: 10.1371/journal.pone.0213624. eCollection 2019.

Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk

Ricardo Usategui-Martín  1 , Salvador Pastor-Idoate  1   2   3 , Antonio J Chamorro  4   5 , Itziar Fernández  1   6   7 , Iván Fernández-Bueno  1   3   8 , Miguel Marcos-Martín  4   5   9 , Rogelio González-Sarmiento  5   9   10 , José Carlos Pastor  1   2   3   8
Affiliations
Meta-Analysis

Meta-analysis of the rs243865 MMP-2 polymorphism and age-related macular degeneration risk

Ricardo Usategui-Martín et al. PLoS One. .

Abstract

Purpose: Several researchers have suggested that the rs243865 (16q13-q21) polymorphism in the promoter region of the metalloproteinase-2 (MMP-2) gene could be associated with an increased risk of developing age-related macular degeneration (AMD). However, previous results remain inconclusive. To clarify this controversy, we conducted a meta-analysis of the relationship between rs243865 of MMP-2 and AMD.

Methods: We included 6 independent case-control studies involving 1,682 AMD patients and 2,295 healthy subjects. The association between the rs243865 polymorphism and AMD was examined by the overall odds ratio (OR) with a 95% confidence interval (CI). We used a recessive genetic model analysis, sensitivity analysis, and assessment of bias in our meta-analysis.

Results: Our results showed that there was no significant association between the variant T allele (p-value = 0.10, OR [95%CI] = 0.95 [0.82-1.10]) or the CT+TT genotype (p-value = 0.16, OR [95%CI] = 0.92 [0.76-1.12]) of rs243865 MMP-2 polymorphism and the presence of AMD.

Conclusions: The rs243865 MMP-2 polymorphism was not associated with an increased risk of developing AMD. The MMP-2 (-1306 C>T) promoter variant is unlikely to have a major role in AMD risk susceptibility.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow chart of the selection of studies for inclusion in the meta-analysis.
Fig 2
Fig 2. Meta-analysis of the association between rs243865 MMP-2 polymorphism and age-related macular degeneration.
(A) C vs. T allele. Test for overall effect: Z = 0.67 (P = 0.50). Test for heterogeneity: v2 = 9.17 (P = 0.10). Test for inconsistency: I2 = 46%. (B) CC vs. CT+TT genotype. Test for overall effect: Z = 0.82 (P = 0.41). Test for heterogeneity: v2 = 6.55 (P = 0.16), Test for inconsistency: I2 = 39%. Each study is shown by an OR estimate with the corresponding 95% CI.
Fig 3
Fig 3. Funnel plot of studies included in the meta-analysis assessing the association of the rs243865 MMP-2 polymorphism with age-related macular degeneration.
The effect size (OR) was plotted on the x-axis, and the inverse of variance of the effect was plotted on the y-axis. (A) C vs. T allele. (B) CC vs. CT+TT genotype.
See this image and copyright information in PMC

References

    1. Wang JJ, Foran S, Mitchell P. Age-specific prevalence and causes of bilateral and unilateral visual impairment in older Australians: the Blue Mountains Eye Study. Clin Experiment Ophthalmol. 2000. August;28(4):268–73. - PubMed
    1. Wong WL, Su X, Li X, Cheung CMG, Klein R, Cheng C-Y, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014. February;2(2):e106–116. 10.1016/S2214-109X(13)70145-1 - DOI - PubMed
    1. Jonasson F, Arnarsson A, Eiríksdottir G, Harris TB, Launer LJ, Meuer SM, et al. Prevalence of age-related macular degeneration in old persons: Age, Gene/environment Susceptibility Reykjavik Study. Ophthalmology. 2011. May;118(5):825–30. 10.1016/j.ophtha.2010.08.044 - DOI - PMC - PubMed
    1. Ferris FL, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, et al. Clinical classification of age-related macular degeneration. Ophthalmology. 2013. April;120(4):844–51. 10.1016/j.ophtha.2012.10.036 - DOI - PMC - PubMed
    1. Zarbin MA. Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol. 2004. April;122(4):598–614. 10.1001/archopht.122.4.598 - DOI - PubMed

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