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Review
. 2019 Mar 6;20(5):1132.
doi: 10.3390/ijms20051132.

Clinical Potential and Current Progress of Dental Pulp Stem Cells for Various Systemic Diseases in Regenerative Medicine: A Concise Review

Yoichi Yamada  1   2 , Sayaka Nakamura-Yamada  3 , Kaoru Kusano  4 , Shunsuke Baba  5
Affiliations
Review

Clinical Potential and Current Progress of Dental Pulp Stem Cells for Various Systemic Diseases in Regenerative Medicine: A Concise Review

Yoichi Yamada et al. Int J Mol Sci. .

Abstract

Dental pulp stem cells (DPSCs) are mesenchymal stem cells (MSCs) that have multipotent differentiation and a self-renewal ability. They have been useful not only for dental diseases, but also for systemic diseases. Extensive studies have suggested that DPSCs are effective for various diseases, such as spinal cord injuries, Parkinson's disease, Alzheimer's disease, cerebral ischemia, myocardial infarction, muscular dystrophy, diabetes, liver diseases, eye diseases, immune diseases, and oral diseases. DPSCs have the potential for use in a cell-therapeutic paradigm shift to treat these diseases. It has also been reported that DPSCs have higher regenerative potential than the bone marrow-derived mesenchymal stem cells known as representative MSCs. Therefore, DPSCs have recently gathered much attention. In this review, the therapeutic potential of DPSCs, the latest progress in the pre-clinical study for treatment of these various systemic diseases, and the clinical applications of DPSCs in regenerative medicine, are all summarized. Although challenges, including mechanisms of the effects and establishment of cell processing and transplantation methods for clinical use, still remain, DPSCs could be promising stem cells sources for various clinical applications, because of their easy isolation by a noninvasive procedure without ethical concerns.

Keywords: clinical application; dental pulp stem cells (DPSCs); mesenchymal stem cells; stem cell therapy; systemic disease.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Characteristics of dental pulp stem cells (DPSCs). DPSCs can be obtained from dental pulp tissue and possess self-renewal and multilineage differentiation potential. DPSCs expressed mesenchymal stem cell (MSC) markers resembling those of bone-marrow-derived MSCs (BMMSCs).
Figure 2
Figure 2
Application of DPSCs for treating various disorders. Transplantation of DPSCs or DPSC- derived differentiated cells is beneficial not only for oral diseases, but also for systemic diseases such as neurological disease, circulatory disease, internal disease, orthopedic disorders, and eye disease.
See this image and copyright information in PMC

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